前列通片的制备工艺研究  

Study on Extracting Process and Preparation of Qianlietong Tablet

作　　者：李瑞海[1] 程岚[1] 赵琳[1] 吕佳[1] 陈翠英[1] 陈剑锋 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁成大方圆医药连锁有限公司,辽宁沈阳110001

出　　处：《辽宁中医杂志》2006年第5期606-607,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省委课题(20040226)

摘　　要：目的:前列通片的提取工艺及成品制备工艺研究。方法:通过正交试验以处方中金银花中所含主要成分绿原酸的提取量和出膏率为定量指标,确定合理的水提取工艺,同时确定成型工艺条件。结果:水提取最佳工艺条件是:加水量为6、4、4倍,提取3次,每次提取1h,出膏率及有效成分提取率均较高,且重现性较好。以糊精为填充剂,以60%乙醇为润湿剂,以羧甲基淀粉钠为崩解剂。结论:优选得到的工艺稳定可行,适合工业大生产要求。Objective： To study the optimum extracting process and preparation of Qianlietong tablet. Methods：The proper extracting conditions are optimized by orthogonal tests with the amount of extracted chlorogenic acid as index. Results：The proper decocting condition： the proper extracting condition with water： the herbsare extracted with 6, 4 and 4 times for 3 times while 1 hours each time. Conclusion： Optimized process condition is scientific, stable and practicable in manufacture.

关 键 词：提取工艺 正交设计 制备工艺 HPLC 绿原酸 

分 类 号：R283[医药卫生—中药学]