2-(氰基甲硫基)乙酸  

2-Cyanomethylthioacetic Acid

作　　者：田铁牛[1] 赵有贵[1] 王荣耕[2] 

机构地区：[1]河北化工医药职业技术学院,河北石家庄050031 [2]河北科技大学,河北石家庄050018

出　　处：《精细与专用化学品》2006年第10期10-11,共2页Fine and Specialty Chemicals

摘　　要：以巯基甲酸乙酯与氯乙腈为起始原料,经过缩合、水解、精制等步骤,合成了头孢美唑的重要中间体——2-(氰基甲硫基)乙酸,还将该产品制备成钾盐、钠盐和酰氯。2-(氰基甲硫基)乙酸的总收率达到50%。Using ethyl mercaptoformatc and chloroacetonitrile as raw materials, the 2-cyanomethyhhioacetic acid, an important intermediate of Cefmetazole, was synthesized through condensation, hydrolysis and purification, its potassium salt, sodium salt and acyl chloride were also synthesized. The total yield of 2-cyanomethyhhioacetic acid was reached up to 50%.

关 键 词：头孢美唑 2-(氰基甲硫基)乙酸 2-(氰基甲硫基)乙酰氯 2-(氰基甲硫基)乙酸钠 2-(氰基甲硫基)乙酸钾 

分 类 号：TQ225.1[化学工程—有机化工]