30S核糖体的结构及其与氨基糖苷类抗生素相互作用的新进展  

Recent advances on the structure of 30 S ribosomal subunit and interaction of 30 S ribosome with aminoglycosides

作　　者：范铭琦[1] 赵敏[2] 范瑾[2] 

机构地区：[1]英国诺丁汉大学生物学院 [2]江苏省微生物研究所,无锡214063

出　　处：《中国新药杂志》2006年第9期676-682,共7页Chinese Journal of New Drugs

摘　　要：氨基糖苷类抗生素(AGs)是临床上广泛应用的抗生素之一,其靶位是细菌的30S核糖体。现综述30S核糖体的精确结构及几种AGs如链霉素、巴龙霉素、庆大霉素C_(1a)、妥市霉素、潮霉素B、Geneticin与30S核糖体结合方式,从分子水平上理解AGs的作用机制、构效关系和耐药性、指导设计新的抗生素。Aminoglyeoside antibiotics are one of the most widely used antibacterial agents in clinic. They inhibit bacterial protein synthesis by binding to the 30 S ribosomal subunit and then disrupt the normal function of ribosome. Recently, the fine structures of bacterial 30 S ribosomal subunits and their complexes bound to various aminoglycosides have been revealed. Such progress makes it possible for us to understand the mechanism of the action, resistance and structure-function relationship of aminoglycosides in molecular details, establishing a rational to develop novel antibiotics. This paper briefly reviewed these recent progresses.

关 键 词：30S核糖体 分子结构 氨基糖苷类抗生素 

分 类 号：R978.1[医药卫生—药品]