NF-κB/IκB信号通路在乙型肝炎病毒相关性肾炎肾组织中的表达  

Expression of NF-κB/IκB signal pathway in renal tissues of hepatitis B virus-associated nephritis

作　　者：于艳[1] 王汉民[1] 张静[2] 陈威[1] 崔继红[2] 刘彦仿[2] 连耀国[1] 

机构地区：[1]第四军医大学西京医院肾内科,陕西西安710032 [2]第四军医大学西京医院病理科,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2006年第3期327-329,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金资助项目(No.30400213)

摘　　要：目的探讨核转录因子-κB(NF-κB)/IκB在乙型肝炎病毒相关性肾炎(HBVGN)肾组织中的表达及其在HBVGN发病机制中的可能作用。方法采用免疫组化染色法,检测42例HBVGN、20例原发性膜性肾病及5例正常肾组织中NF-κBp65、IκB-α蛋白的表达。结果NF-κBp65蛋白在HB-VGN组织中的表达,明显高于在原发性膜性肾病(P<0.01)及正常肾组织(P<0.05)中的表达,且细胞核和细胞质中都可检测到NF-κBp65的表达;相反IκB-α在HBVGN组织中的表达低于原发性膜性肾病肾组织(P<0.05)。结论HBVGN肾组织可能有IκB-α蛋白降解及NF-κB核转移。NF-κB/IκB可能参与了肾组织的病理损害过程。AIM： To investigate the expression of nuclear transcription factor-kappa B （ NF-κB）/IκB in renal tissues of hepatitis B virus-associated nephritis （ HBVGN ） and its role in the pathogenesis of HBVGN. METHODS： The expression of NF-κB p65 and IκB-α in renal tissues were examined in biopsy specimens from 42 HBVGN patients, 20 patients with primary membranous nephropathy and 5 normal subjects by immunohisto-chemical staining. RESULTS： The NF-κB p65 expression in glomerular and tubular of HBVGN tissues was notably higher than that in normal control tissues（P〈0.05） and in primary membranous nephropathy tissues（ P〈0.01 ）. The IκB-α expression in glomerular and tubular of HBVGN tissues was lower than that in primary membranous nephropathy tissues （ P 〈 0. 05 ）. CONCLUSION： There might be protein degradation of IκB-α and nuclear translocation of NF-κB in renal tissues of HBVGN, which suggests that NF-κB/IκB signal pathway may play an important role in the pathogenesis of HBVGN.

关 键 词：乙型肝炎病毒相关性肾炎 核转录因子-ΚB IΚB 免疫组织化学染色 

分 类 号：R692.3[医药卫生—泌尿科学]