调脂治疗对胰岛β细胞功能影响临床观察  

A clingical study of lipid-modnlating thetrapy on islet β-cell

作　　者：孙虹云[1] 

机构地区：[1]蚌埠市第三人民医院肾脏内分泌科,233000

出　　处：《安徽医学》2006年第3期189-190,共2页Anhui Medical Journal

摘　　要：目的观察2型糖尿病患者调脂治疗前后胰岛β细胞功能变化。方法2型糖尿病并高脂血症者,以标准馒头餐试验中空腹C肽,餐后30分钟C肽,作为反映葡萄糖刺激β细胞胰岛素分泌功能,然后分调脂治疗组、未调脂治疗组作为对照,均采用治疗6个月后,观察两组葡萄糖刺激的胰岛素分泌。结果调脂治疗组,餐后30分钟C肽分泌与治疗前相比显著增加。结论调脂治疗后,解除脂毒性可使β细胞功能得到相应改善。Objective To observe the effects of Lipid-modulating therapy on islet β cell function in 2-type diabetes patients. Methods 2-type diabetes patients with hyper lipidemia were selected. Fasting plasma c-peptide and postprandial 30 mins c-peptide of standard steamed bread c-peptide releasing test （SSBT） ware performed to measure β- cell function during OGTT. These diabetic patients were divided into taking lipid- modalating and non- lipid- modalating. After six months of treating. To observe double function of insulin secretion of islet β-cells during OGTT. Results Compared with treatment before in the group of lipid-modalation therapy. Postprandial 30 mins plasma. C-peptide secreation level was sigrificantly raised. Conclusion The treatment of lipid modulating therapy can release the lipotoxieity and improve the β-cell function.

关 键 词：胰岛素 脂毒性 Β细胞功能 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]