基于移动介电笼的生物粒子分离  

Separation of bio-particles based on moving dielectrophoretic cages

作　　者：朱树存[1] 易红[1] 倪中华[1] 

机构地区：[1]东南大学机械工程学院,南京210096

出　　处：《东南大学学报（自然科学版）》2006年第3期380-383,共4页Journal of Southeast University：Natural Science Edition

基　　金：教育部科学技术研究重点资助项目(106083);江苏省自然科学基金资助项目(BK20055072)

摘　　要：针对目前介电泳分离芯片存在的问题,从与芯片实验室系统的集成性、分离的准确性、分离对象的多样性以及灵活性等综合指标分析,提出了基于移动介电笼的分离新方法.并根据Maxwell应力张量法构建了面向纳米级病毒分子的电极特征尺寸为500 nm的移动介电笼分离芯片,同时对实现新型分离芯片所涉及的基本原理、芯片物理模型以及相关三维电极阵列的结构设计和加工工艺等方面进行了研究,最后应用FEMLAB对介电笼的移动过程进行了数值仿真,验证了所设计模型的可行性.To overcome the shortcoming of current dielectrophoretic separation in lab-on-a-chip systems a novel separation approach based on moving dielectrophoretic cages（MDC） is proposed from the comprehensive indices of the integration of lab-on-a-chip systems, the correctness of separation, the object variety of separation, and the flexibility of separation etc. Based on the Maxwell stress tensor（MST） calculation, a MDC separation chip is developed towards nanoscale virus molecule separation, the characteristic size of the electrode being 500 nm. Meanwhile, the corresponding key technology of the MDC separation chip are studied, including the basic theory of MDC, the physical model of separation chip, the structure design of 3D electrodes and the chip fabrication process. Finally, the simulation of dielectrophoretic cages motion is presented by using FEMLAB to verify the feasibility of the new separation chip model.

关 键 词：纳米介电泳 移动介电笼 芯片实验室 生物粒子分离 

分 类 号：R318.11[医药卫生—生物医学工程]