纳米氧化铝对小鼠血清生化指标的影响  

The effect of nano-alumina on serum biochemical index in mice

作　　者：王天成[1] 孙红芳[2] 贾光[3] 沈惠麒[3] 赵宇亮[4] 

机构地区：[1]北京大学第三医院检验科,北京100083 [2]北京大学化学与分子工程学院化学生物学系,100871 [3]北京大学医学部公共卫生学院劳动卫生与环境卫生学系,100083 [4]中国科学院高能物理研究所,100049

出　　处：《中国职业医学》2006年第3期171-173,共3页China Occupational Medicine

基　　金：国家十五重大项目(编号:10490180)

摘　　要：目的探讨纳米氧化铝(nano-A l2O3)对小鼠血清生化指标的影响。方法30只CD小鼠随机分为对照、nano-A l2O3和微米氧化铝(m icron-A l2O3)3组,以5 g/kg nano-A l2O3或m icron-A l2O3一次经口灌胃,14 d后处死观察血清生化指标的变化。结果nano-A l2O3组小鼠血清尿酸(UA)明显低于m icron-A l2O3组;m icron-A l2O3组丙氨酸转氨酶(ALT)明显低于nano-A l2O3组(P<0.05)。nano-A l2O3组小鼠血清乳酸脱氢酶(LDH)、α羟丁酸脱氢酶(HBDH)和UA与对照组相比有明显降低,碱性磷酸酶(ALP)、三酰甘油(TC)和葡萄糖(GLU)明显升高(P<0.05);总胆固醇(TG)、高密度脂蛋白胆固醇(HDL-C)有所升高,但与对照组相比差异无显著性(P>0.05)。与对照组相比,m icron-A l2O3组小鼠血清ALT、UA和白蛋白(ALB)明显降低,TG、TC和HDL-C显著升高(P<0.05)。结论nano-A l2O3对小鼠血清生化指标的影响与m icron-A l2O3有所不同。Objective To explore the effect of nano-Al2O3 on mice serum biochemical indexes. Methods 30 CD mice were divided into control group, nano-Al2O3 group and micron-Al2O3 group and were treated with a single oral dose of nano-or micron-Al2O3 at 5.0 g/kg body weight by garage. 14 days after the treatment, the mice were sacrificed and the serum was collected for biochemical analysis. Results Serum UA in nano-Al2O3 group was lower than that in micron-Al2O3 group and serum ALT in micron- Al2O3 group was significantly lower than that in nano-Al2O3 group （P 〈 0. 05）. Serum LDH, HBDH, UA in nano-Al2O3 group were obviously lower and ALP, TG, GLU were significantly higher than those in control group （P 〈 0. 05 ）, sermn TCHO and HDL-C were higher than those in control group but there were not significant differences （P 〉 0.05）. In micron-Al2O3 group, serum ALT, UA, ALB were lower and TCHO, TG, HDL-C were obviously higher than those in control group （P 〈0. 05）. Conclusion nano-Al2O3 may have some different effects on mice serum biochemical indexes as compared with those of micron-Al2O3.

关 键 词：纳米材料 氧化铝 血清生化指标 

分 类 号：R114[医药卫生—卫生毒理学] R135.1[医药卫生—公共卫生与预防医学]