再生障碍性贫血患者外周血单个核细胞培养上清液IL-6和TNF活性测定及其意义  

An Assay of IL-6 and TNF level in Culture Supernatant of PBM-NC from Patients with Aplastic Anemia

作　　者：王俊容[1] 黄宗干[1] 

机构地区：[1]重庆医科大学附属第一医院,广东省三水市人民医院内科528100

出　　处：《临床血液学杂志》1996年第1期10-13,共4页Journal of Clinical Hematology

摘　　要：测定18例再障患者PBMNC诱生IL-6活性和诱生TNF及血浆TNF水平.结果显示PBMNC诱生IL-6活性和诱生TNF及血浆TNF水平均明显增高(P<0.05),诱生IL-6活性在急性型再障高于慢性型(P<0.05).TNF是一种造血抑制因子,对再障的发病起了重要作用.IL-6的增高提示为机体的一种保护性代偿反应.Tumor necrosis factor (TNF) level in plasma and production induced JNG and interleukin-6 (IL-6) level in culture supernatant of peripheral blood mononuclear cells (PBMNC) had investigated in 18 patients with aplastic anemia(AA). The results showed that the TNF and IL-6 levels in AA were singificantly higher than that of normal controls(P<0. 05),there were also positive correction between IL-6 and TNF levels.It is suggested that TNF is hemopoietic inhibitor which play an important role in pathe-genesis in AA,lncreament of IL-6 in AA is assumed to be a protective compensation im human body.

关 键 词：再生障碍性贫血 白细胞介素6 肿瘤坏死因子 

分 类 号：R556.5[医药卫生—血液循环系统疾病]