催产素改善卡那霉素所致听力损伤的实验研究  

Experimental Study on the Therapeutic Value of Oxytocin on Hearing Loss due to Kanamycin

作　　者：童素琴[1] 刘建瓴[1] 董维嘉[1] 朱朝[1] 王秋严[1] 胡联[1] 

机构地区：[1]南京铁道医学院听力研究室

出　　处：《南京铁道医学院学报》1996年第2期65-69,共5页Journal of Nanjing Railway Medical College

基　　金：国家自然科学基金

摘　　要：目的：观察催产素（ＯＸＴ）对卡那霉素所致听力损伤的治疗作用。方法：建立中度及重度耳中毒动物模型。采用听觉电生理指标和耳蜗基底膜铺片技术。结果：中度听力损伤组用ＯＸＴ治疗后，听觉脑干诱发电位（ＡＢＲ）Ⅳ波反应阈较治疗前明显下降，耳蜗二、三回外毛细胞损伤程度较对照组明显减轻，蜗内直流电位负相成分（Ｎ－ＥＰ）绝对值较大；在重度听力损伤组中，ＯＸＴ治疗组和对照组上述指标均无显著差异。结论：用本实验剂量的ＯＸＴ对中度听力损伤有明显的治疗作用，对重度听力损伤的治疗作用不明显。OBJECTIVES: To evaluate the therapeutic effect of oxytocin (OXT) on the hearing loss due to kanamycin. METHODS: Animal models of mild and heavy hearing loss were established using guinea pigs. The electrophysiological signal of auditory was recorded and endocochlear histochemistric techllique was used. RESULTS: In the mild hearing loss model, OXT injecticl bagsed a decrease in threshold of acoustic brainstem evoked response and a significant increase in absolute value of negative endocochlear potential. Damage of oUter hair cells in the second and third turns was significantly milder in experiment group than in control. Those abovementioned in heavy hearing loss model had no significant difference between experimental and control groups. CONCLUSIONS: OXT is suggested to have a therapeutic effect on mild hearing loss due to kanamycin.

关 键 词：催产素 卡那霉素 听力损伤 豚鼠 实验 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]