中性粒细胞在肝脏缺血再灌注损伤中的意义及海风藤酮的保护作用  

The Role of Neutrophils in Hepatic Ischemia-Reperfusion Injury and the Protective Effect of Kadsurenone

作　　者：史留斌[1] 陈怀仁[1] 

机构地区：[1]南京铁道医学院附属医院胆道外科

出　　处：《南京铁道医学院学报》1996年第2期83-86,共4页Journal of Nanjing Railway Medical College

摘　　要：目的：探讨中性粒细胞在肝脏缺血再灌注损伤中的意义及海风藤酮的保护作用。方法：测定大鼠肝脏局部缺血再灌注损伤及预防性应用海风藤酮时肝胆汁流量、肝组织丙二醛含量、肝脏病理变化及中性粒细胞浸润程度。结果：随着肝脏缺血再灌注时间的延长，肝组织中性粒细胞浸润程度逐渐加重；海风藤酮可以减轻肝脏脂质过氧化及炎症损伤程度，显著改善肝脏损伤后的胆汁流量。结论：中性粒细胞在肝脏缺血再灌注损伤中起重要作用，其作用可以被血小板激活因子拮抗剂海风藤酮所拮抗。OBJECTIVE:To study the role of neutrophils in hepatic ischemia-reperfusion injury and the prevelltive effects of Kadsurenone. METHODS:The bile flow,levels of malondialdehyde (MDA) in the hepafic tissues were measured in hepatic iscllemia-reperfusion injury in rats with or without administration of kadsurenone. The pathological changes in hepatic tissues and the degree of neutrophll infiltration were aslo measured. RESULTS: As the liver reperfusion prolonged, the neutrophil infiltratioll degree was increasillg. After administration of kadsurenone intravenously, the liver tissue MDA, bile flow and the degree of neutrophil infiltration were significantly lower that those of tlntreated groups(p<0. 001 ). CONCLUSLONS:Neutrophils play an important role in liver iscllemia-reperfusion injury and its deleterious effects can be blocked by kadsurenone.

关 键 词：肝脏 缺血再灌注损伤 中性粒细胞 海风藤酮 

分 类 号：R657.3[医药卫生—外科学]