Ramipril的血流动力学作用及其作用机制  

Ramipril in Treatment of Congestive Heart Failure: Hemodynamic Efficacy and its Mechanism

作　　者：王振兴[1] 陈日新[1] 张子沪[1] 张丽蓉[1] 李卓雄 

机构地区：[1]南京铁道医学院附属医院心脏科,南京铁路医院心脏科

出　　处：《南京铁道医学院学报》1996年第2期97-100,共4页Journal of Nanjing Railway Medical College

摘　　要：目的：明确ｒａｍｉｐｒｉｌ治疗心力衰竭的效应及其作用机制。方法：１２名重度心力衰竭患者口服ｒａｍｉｐｒｉｌ５ｍｇ，观察服药后２４ｈ血流动力学变化。放免法测定服药前后血浆肾素活力（ＰＲＡ）和血管紧张素Ⅱ（ＡｎｇⅡ）浓度，紫外法测定血管紧张素转化酶（ＡＣＥ）活力的变化。结果：服药后２ｈ即可见有明显的血流动力学改善，最大效应出现在服药后４ｈ，一次服药作用可维持２４ｈ。Ｒａｍｉｐｒｉｌ使ＡＣＥ活力和ＡｎｇⅡ浓度明显而持久地降低，ＰＲＡ反应性增高。结论：Ｒａｍｉｐｒｉｌ是一种作用强大的长效ＡＣＥ抑制剂，可望成为治疗严重心力衰竭的安全有效药物。OBJECTIVES: To determine the efficacy and the mechanism of ramipril in treatment of congestive heart failure. METHODS:Twelve patients with severe congestive heart failure were treated with ramipril 5 mg. The hemodynamic effects were observed with a Swan-Ganz catheter over 24h.Plasma renin actlvltyandanglotensl concentration weredetermlned byradloimmunoassay.Angiotensin-converting enzyme(ACE)activity was determined by colorimetric method.RESULTS:Ramipril achived benificial hemodynamlc effects within 2h after dosing,maximal imrovement was observed within 4h,and the beneficial hemodynamic changes lasted for 24h.Ramipril Induced a pronounced,sustained decrease in ACE activity and plasma angiotensin Ⅱ conCentration, and an increase in plasma renin activity. CONCLUTIONS: Ramipril is a potent long acting ACE inhibitor that is expected to bebeneficial in treatment of patients with cardlac failure.

关 键 词：ACEI 充血性 心力衰竭 血液动力学 

分 类 号：R972.4[医药卫生—药品]