钼对缺硒大鼠心肌线粒体功能的影响  

Effect of Molybdenum of the Functions of Heart Respiratory Chain in Se-Deficient Rats

作　　者：李信民[1] 李广元[1] 

机构地区：[1]西安医科大学中西医结合研究所

出　　处：《地方病通报》1996年第2期13-14,共2页Endemic Diseases Bulletin

摘　　要：本文以克山病病区粮喂养大白鼠造成缺硒动物模型，以病区粮加钼作为处理因素，对大鼠心肌线粒体ＳＤＨ，ＣＣＯ活力及氧化磷酸化效率（Ｐ／Ｏ比值）做了测定。结果显示，钼对上述测定指标均有不同程度的改善，大剂量钼（４０ｍｇ／ｋｇ饲料）的作用优于小剂量钼（２．０ｍｇ／ｋｇ饲料），且与对照组相比有显著的统计学意义。此外，小剂量钼也能明显提高心肌线粒体ＳＤＨ活力。实验结果提示，改善心肌线粒体呼吸链功能及氧化磷酸化效率，是钼保护心肌的可能途径之一。The effect of molybdenum on chondriosome of myocardium was studied in Se-deficient rats fedon Se-deficient food to test SDH,CCO and P/O ratio. The results show that molybdenum can improve the in-dices mentioned above. Complement of 40 mg molybdenum per kg of food is better than that of 2. 0 mg andthe effect of more molybdenum is statistically significant compared with the control.Small amount of molyb- denum also can increase the activities of SDH distinctly. These suggest that the improvement of the myocardi- um chondriosome functions be due to molybdenum which will protect myocardinum from the damage.

关 键 词：钼 琥珀酸脱氢酶 细胞色素氧化酶 心肌 克山病 

分 类 号：R542.302[医药卫生—心血管疾病]