Total Synthesis of N-Methylsansalvamide A  

作　　者：Shou Xin LIU Yan Lou GENG Xia TIAN Xiao Li ZHEN Jian Rong HAN 

机构地区：[1]College of chemical ＆ pharmaceutical Engineering, Hebei University of Science ＆ Tecnnology, Shijiazhuang 050018

出　　处：《Chinese Chemical Letters》2006年第6期761-764,共4页中国化学快报（英文版）

基　　金：The authors are grateful to The National Natural Science Foundation of China （No.30472074） ; to The Hebei province Natural Science Foundation （No.B2006000302） for financial support of this work.

摘　　要：Total synthesis of N-methylsansalvamide A was accomplished in solution phase by a convergent approach. An N-Boc-td-depsipepide 6 and a dipeptide ester 10 were prepared in the yield of 89% and 91%, respectively. Cyclization of the linear penta-depsipetide was achieved with PyBOP and DIPEA in DMF-CH2C12.Total synthesis of N-methylsansalvamide A was accomplished in solution phase by a convergent approach. An N-Boc-td-depsipepide 6 and a dipeptide ester 10 were prepared in the yield of 89% and 91%, respectively. Cyclization of the linear penta-depsipetide was achieved with PyBOP and DIPEA in DMF-CH2C12.

关 键 词：SYNTHESIS N-methylsansalvamide A solution phase cyclic depsipeptide. 

分 类 号：R979.1[医药卫生—药品] R914[医药卫生—药学]