磁场对AMI大鼠心肌ATP及血浆cAMP、cGMP的影响  

The influence of magnetic field on ATP、cAMP and cGMP of big rats with AMI

作　　者：赵锐[1] 周慧颖[2] 初秋[1] 平世荣[1] 

机构地区：[1]北华大学医学院生化教研室,吉林132013 [2]浙江财经大学物理教研室

出　　处：《中国地方病防治》2006年第3期144-145,共2页Chinese Journal of Control of Endemic Diseases

基　　金：吉林省教育厅资助课题(2003029)

摘　　要：目的探讨磁场对AM I的保护作用。方法将大鼠随机分为5组即:空白对照组、磁场对照组、AM I组、AM I药物(心得安)治疗组和AM I磁场治疗组。采用虫荧光素酶法及放射免疫技术法对实验性大鼠进行心肌ATP含量、及血浆cAMP、cGMP的测定。结果AM I磁场治疗组心肌ATP明显高于AM I组(P<0.01)与药物治疗组相近似。AM I的血浆cAMP、cGMP含量明显高于空白对照组(P<0.01)及磁场对照组,AM I磁场治疗组与药物治疗组明显低于AM I组(P<0.01)。结论磁场能降低AM I大鼠cAMP、cGMP的含量,增加心肌ATP含量,对心肌具有保护作用,这也为磁场用于AM I的治疗提供了实验依据。Objective This paper studied protective effect of magnetic field on AMI big rats. Methods The big rats were randomly divided into 5 groups： the blank contrast（ G1 ）, the magnetic field contrast（ G2 ）, AMI group （G3 ）, AMI drug （propranolol） group （ G4 ） and AMI magnetic field （ G5 ）, Results The contents of myocardium ATP were higher than those of G3 （ P 〈 0.01 ）. Plasma cAMP,cGMP of G3 were obviously higher than G1 （ P 〈 0.01 ）, G5 were similar to those of G4. Conclusions The magnetic field has protective effect on experimental AMI myocardium.

关 键 词：磁场 急性心肌梗塞(AMI) ATP CAMP CGMP 

分 类 号：R542.4[医药卫生—心血管疾病]