静脉注射不同剂量氯胺酮对学龄前小儿心率变异功率谱的影响  

Effects of Different Doses of Ketamine on Heart Rate Variability of Preschool Children

作　　者：刘子健[1] 

机构地区：[1]深圳市儿童医院麻醉科,深圳518026

出　　处：《临床小儿外科杂志》2006年第2期102-104,共3页Journal of Clinical Pediatric Surgery

摘　　要：目的通过观察不同剂量氯胺酮对学龄前小儿心率变异功率谱的影响,总结出能直观反映小儿氯胺酮麻醉深度的量化指标。方法选择5～6岁小儿54例,随机分为A、B两组,分别静脉注射氯胺酮(Ketamine,KTM)1mg.kg-1、2mg.kg-1,比较组内不同时点、组间同时点心率变异功率谱中各指标的变化。结果静脉注射氯胺酮后,A、B两组心率变异功率谱中,除了心率(HR)外,其余成分值较基础值均下降(P<0.05)。组间比较:B组低频(LF)、高频(HF)、心率变异指数(HRVI)比A组小(P<0.05)。结论静脉注射氯胺酮后心率变异功率谱中除HR外,其他成分值下降且幅度与剂量有关,其中HRVI变化最为直观敏感,可作为麻醉深度的监测指标。Objective To compare all parameters in HRV-PSA, which were influenced by the different dosage of ketamine during pediatric anesthesia,to seek the sensitive and quantitative parameters, which could objectively monitor the depth of pediatric anesthesia. Methods 54 cases age ranged from 5 to 6 years, ASA Ⅰ-Ⅱ were selected and randomly divided into A and B groups. Ketamine lmg.kg^-1 was injected intravenously in group A, while in group B 2mg.kg^-1. Parameters were recorded continuously. These parameters at different times were compared in each group, while those at the same time were compared between two groups. Results Except HR, other determinants in HRV-PSA were reduced significantly in group A and B （P〈0.05）. LF, HF and HRⅥ in group B were significant lower than that in group A （P〈0.05）. Conclusions Except HR, other parameters in HRV-PSA are decreased and decrement is correlated with the doses of ketamine. Among all parameters, HRⅥ is the most directly and sensitive,so it may act as an indicator of monitoring anesthesia depth.

关 键 词：心率 氯胺酮/投药和剂量 输注 静脉内 儿童 学龄前 

分 类 号：R726.1[医药卫生—儿科]