氧化吲哚的绿色合成工艺研究  

Study on green process for synthesis of oxindole

作　　者：蔡可迎[1] 魏贤勇[1] 

机构地区：[1]中国矿业大学化工学院,江苏徐州221008

出　　处：《应用化工》2006年第5期339-341,共3页Applied Chemical Industry

基　　金：江苏高校高新技术产业发展项目(JHB05-33)

摘　　要：以邻硝基甲苯为原料在乙醇钠催化下与草酸二乙酯缩合、水解、双氧水氧化、盐酸酸化得到邻硝基苯乙酸收率为62%。在水溶液中,以FeO(OH)为催化剂,水合肼还原邻硝基苯乙酸得到氧化吲哚。考察了还原过程中影响反应的因素。结果表明,水合肼∶邻硝基苯乙酸=3∶1(摩尔比),催化剂FeO(OH)的用量为0.2 g/mmol邻硝基苯乙酸,溶剂水的用量为5 mL/mmol邻硝基苯乙酸,回流反应1.0 h,氧化吲哚的收率为95%。两步总收率达59%。o-Nitrophenylacetic acid was synthesized by condensation of o-nitrotoluene with diethyl oxalate catalyzed by C2H5ONa, hydrolysis, oxidation with H2O2 and acidation with HCI in about 62% yield. It was further converted to oxindole through reduction by hydrazine hydrate in water, catalyzed by FeO（OH）. The effect of various factors in the process of reduction was investigated. The results showed that under the conditions of the mole ratio of hydrazine hydrate to o-nitrophenylacetie acid is 3 ： 1, the quantity of catalyst FeO（OH） is 0.2 g/retool o-nitrophenylacetic acid, the quantity of water is 5 mL/mmol o-nitrophenylacetic acid and the reaction time for 1.0 h, the yield of oxindole is about 95%. The overall yield is about 59%.

关 键 词：邻硝基苯乙酸 氧化吲哚 水合肼 合成 

分 类 号：TQ251.3[化学工程—有机化工]