头电针对帕金森病患者纹状体区DAT显像影响  

Effect of electro-scalp acupuncture on cerebral dopamine transporter in the striatum area of the patient of Parkinson's disease by means of single photon emission computer tomography

作　　者：姜雪梅[1] 黄泳[1] 李东江[2] 唐安戊[2] 王升旭[1] 卓鹰[1] 李求实[1] 陈静[1] 高彦平[1] 

机构地区：[1]南方医科大学中医药学院,广州510515 [2]广东省人民医院伟伦PET中心

出　　处：《中国针灸》2006年第6期427-430,共4页Chinese Acupuncture & Moxibustion

基　　金：广东省自然基金资助课题:04020389;广东省中医药管理局资助课题:1050131

摘　　要：目的:运用SPECT技术探讨头电针治疗帕金森病(PD)的机理。方法:5例PD患者均接受顶颞前斜线(MS6),额旁3线(MS4),顶旁1线(MS8),顶旁2线(MS9),枕下旁线(MS14)的电针治疗,单侧病变针对侧,双侧病变针双侧。治疗前后分别行99mTc-TRODAT-1SPECT显像,利用感兴趣区(ROI)测定纹状体/枕叶(ST/OC)的比值,分析纹状体区的多巴胺转运体(DAT)活性。结果:治疗前后发病同侧ST/OC分别是1·19±0·15和1·24±0·31,而对侧分别是0·90±0·12和0·95±0·25,治疗后均有增加,但差异无统计学意义(P>0·05)。结论:头电针可以减少PD患者纹状体区DAT的丢失,改善纹状体区DAT的活性。Objective To probe the mechanism of electro-scalp acupuncture in treatment of Parkinson＇s disease （PD） by single photon emission computer tomography （SPECT）. Methods Five cases of PD received electro-scalp acupuncture at Dingnie Qianxiexian （MS 6）, Epangxian Ⅲ（MS 4）, Dingpangxian I （MS 81, Dingpangxian Ⅱ（MS 91 and Zhenxia Pangxian （MS 14） Contralateral points were selected for pathologic change on one side and bilateral points were selected for pathologic lesion on both sides. All the patients received 99mTc-TRODAT-1 SPECT examination before and after acupuncture treatment of 6 weeks. And activities of dopamine transporter （DAT/ were analyzed by the ratio of striatum/occipital lobe （ST/OC）, which was evaluated by means of technique of regional of interesting （RO1）. Results The ratio of ST/OC on the same side of the affected extremity before and after treatment were 1.19±0. 15 and 1.24±0.31 respectively. And on the other side were 0. 90±0. 12 and 0.95±0.25 respectively. They were increased after treatment （P〉0. 05）. Conclusion Electro-scalp acupuncture can decrease the loss of DAT and improve the activities of DAT in the striatum of the patient of PD.

关 键 词：帕金森病/针灸疗法 头针 电针 受体 多巴胺/针灸效应 纹状体/针灸效应 体层摄影术 发射型计算机 单光子 

分 类 号：R246.6[医药卫生—针灸推拿学]