血红蛋白含量与高血压靶器官损伤  

Hemoglobin and Hypertension and the Damage of Target Organs

作　　者：魏玲[1] 杨丽霞[1] 赵颖[1] 王先梅[1] 郭传明[1] 齐峰[1] 任丽[1] 李丽俐[1] 

机构地区：[1]成都军区昆明总医院心内科,云南昆明650032

出　　处：《高血压杂志》2006年第5期360-363,共4页Chinese Journal of Hypertension

摘　　要：目的探讨高血压病患者外周血红蛋白含量(Hb)与高血压及其靶器官损伤(左室肥厚及缺血性脑卒中)的相关性。方法应用血细胞计数器测定Hb,用放免的方法检测促红细胞生成素(Epo),结合超声心动图、头颅CT等检查,观察282例高血压病患者外周血Hb值及其与靶器官损伤的相关性。结果高血压病患者外周血中Hb较正常对照组显著增加[(145.4±20.6比130.3±13.3)g/L,P<0.05],高血压合并左室肥厚及缺血性脑卒中者外周血Hb含量显著高于无左室肥厚及缺血性脑卒中者[(150.5±19.2比139.1±20.2)g/L和(156.8±18.6比138.8±19.9)g/L,P<0.05]。高血压患者外周血Epo与Hb呈弱正相关,Hb增高组Epo显著高于Hb正常组。结论高血压患者Hb浓度可能是高血压病发生靶器官损伤的潜在危险因子之一,Hb增加可能与Epo有关。Objective To investigate the relationship between Hb and hypertension（EH） induced target organ damage. Methods Two hundred eighty two EH patients, average 61.2±13.2 years, male 166 cases and female 116 cases, were underwent Hb and Epo examination with hemocytometer and radioimmunity. LVH was measured by echocardiography. Cerebral infarction was examined by CT. Resalts Hb is significantly increased in EH patients compared with control group （145.4±20.6 vs 130.3±13.3 g/L, P〈0.05）, and increased much more in the patients with target organ damage（Cerebral infarction and LVH： 150.5±19.2 vs 139. 1±20. land 156.8±18.6 vs 138.8±19.9 g/L, P〈0.05）. Correlation analysis showed that Hb correlated positively to the level of Epo. Condnsion Changes in Hb may be associated with the development of LVH and cerebral infarction.

关 键 词：高血压病 左室肥厚 脑卒中 血红蛋白 血黏度 促红细胞生成素 

分 类 号：R544.1[医药卫生—心血管疾病] R135[医药卫生—内科学]