腰神经后根切断对下肢骨生长影响的实验研究  

Effect of lumbar nerve dorsal roots section on the rat bone structural changes of lower limb

作　　者：徐峰[1] 付中国[1] 张殿英[1] 褚亚明[1] 姜保国[1] 

机构地区：[1]北京大学人民医院创伤骨科,北京市100044

出　　处：《中华显微外科杂志》2006年第3期202-205,共4页Chinese Journal of Microsurgery

基　　金：十五国家科技攻关计划-临床医学使用技术研究与应用资助项目(2003BA712A11-11;13)

摘　　要：目的研究大鼠单纯后根神经损伤后对下肢骨骼生长的影响。方法48只Wistar大鼠随机分成实验组和对照组；切除大鼠L_2～L_5双侧脊神经后根1cm神经束,分别检测术后第2、4、8周不同时段实验大鼠双侧股骨的骨密度及骨生物力学特性的改变。结果第2、4、8周时,实验组股骨骨密度平均值分别为(0．221±0．008)g/cm^3、(0．213±0．015)g/cm^3、(0．216±0．105)g/cm^3,对照组分别为(0．223±0．005)g/cm^3、(0．218±0．014)g/cm^3和(0．208±0．111)g/cm^3,两组同期股骨骨密度相比均差异无统计学意义,P＞0．05；第2、4、8周时,实验组股骨最大载荷的平均值分别为(93．64±8．78) N、(89．77±11．18)N、(93．21±8．74)N,虽分别低于同期对照组的(95．94±6．29)N、(91．63±9．43)N、(95．57±8．64)N,但两组同期相比,其差异均无统计学意义,P＞0．05。至股骨最大载荷点能量吸收和至断裂点能量吸收的平均值,两组同期相比同样差异无统计学意义,P＞0．05。结论单纯完全切断部分腰神经后根,短期内对下肢股骨骨密度及骨生物力学的特性的影响是有限的或不明显的。Objective To investigate the rat bone structural changes of lower limb following lumbar nerve dorsal roots section. Methods Forty-eight mature female Wistar rats were divided into posterior radicotomy （PR） and comtrol groups randomly. The bilateral femoral bone mineral density （BMD） and biomechanics characteristics were analyzed 2,4 and 8 weeks after the radicotomy. The same operation except the radicotomy was clone in the sham group. Results In PR group, 2,4, and 8 weeks after the radicotomy, the BMD of femur was （0. 221±0. 008）g/cm^3 ,（0. 213±0. 015） g/cm^3 ,and （0. 216±0. 105） g/cm^3 ,respectively; while that was （0.223±0.005）g/cm^3,（0. 218±0.014）g/cm^3, and （0.208±0. 111）g/cm^3 in control group. No significant difference was observed between the two groups（P 〉0. 05）. In PR group, 2, 4, and 8 weeks after the operation, the mean maximum load in three-point bending test of femun midshaft was（93.64±8.76 ） N, （ 89. 77±11.18 ） N and （ 93. 21±8.74 ） N, respectively, and was lower than the values of the control group at the same time point （95.94±6. 29 ） N, （91.63±9. 43 ） N, （95.57±8.64 ） N, However, there was no significant difference between the two groups（ P 〉 0. 05 ）. Accordingly, there was no significant difference in the energy absorption in femun midshaft between the two groups（ P 〉 0. 05 ）. Conclusion The selective rhizotomies of part lumbar never dorsal roots might not cause the loss of the femur BMD and the change of biomechanics property significantly in short period.

关 键 词：腰神经后根损伤 骨密度 骨生物力学 选择性脊神经后根切断术 下肢骨生长 

分 类 号：R651[医药卫生—外科学]