超声引导下射频消融治疗肝癌的临床价值  

Clinical Value of Ultransound-guided Radio-frequency Ablation on Hepatic Carcinoma

作　　者：刘静[1] 张志明[1] 方苇[1] 张晓东[1] 王艳清[1] 郑碧玉[1] 

机构地区：[1]福建医科大学附属厦门市第一医院超声科,福建省361001

出　　处：《中国超声诊断杂志》2006年第6期423-425,共3页Chinese Journal of Ultrasound Diagnosis

摘　　要：目的探讨超声引导下射频消融(RFA)治疗肝癌的疗效。方法35例肝癌49个病灶行超声引导下RFA治疗,对治疗前后病灶的超声影像、超声造影、螺旋CT检查、肝功能、AFP变化以及机体免疫功能的影响等进行综合研究以评价疗效。结果RFA后5min,超声造影,肿块中83.7%(41/49)各个时相无增强,即回声缺失;1周后彩超示肿块中87.8%(43/49)血流信号明显减少或消失;1个月后螺旋CT扫描肿块中81.6%(40/49)大小无明显变化,但肿块内无强化。肝功能有不同程度改善,甲胎蛋白下降,CD4+、CD4+/CD8+明显升高,sIL-2R明显降低。结论超声引导下射频消融治疗肝癌是有效的微创治疗手段,其为操作简便、损伤小、安全性高的有效方法。Objective To evaluate the clinical value of ultrasound-guided radio-frequency ablation （RFA） in treating liver cancer. Methods Thirty-five cases （49 tumors） with hepatocellular carcinoma were treated by ultrasound-guided radio frequency ablation （RFA） The changes of tumors after RFA were evaluated with color Doppler ultrasonography, contrast-enhanced ultrasonography, spiral CT, hepatic function examination, alpha fetoprotein （AFP） and the immune state. Results After five minutes of RFA, 83.7% tumors （41/49） were not changed in contrast-enhanced ultrasonography at every phase ; after one week, the blood stream signals of 87.8% tumors （43/49） were obviously reduced or disappeared on color Doppler ultrasonography; after one month, spiral CT showed that the size of lesions in 81.6% tumors （40/49） bad no variability, but the tumors exhibited attenuation at the arterial phase and the portal venous plase and the hepatic function was improved; the AFP was decreased, CD4＋and CD4＋/CDS＋ values were increased and sIL-2R were markedly decreased. Conclusions Radio-frequency ablation under ultrasonic guidance is a simple, safe, effective and micro-invasive method in the treatment of hepatocellular carcinoma.

关 键 词：超声引导 射频消融 肝癌 

分 类 号：R541.71[医药卫生—心血管疾病] R714.221[医药卫生—内科学]