序贯结肠透析治疗早中期慢性肾功能衰竭的临床研究  

Clinical study on effect of sequential colon dialysis in patients with chronic renal failure in early and medium stage

作　　者：黄远航[1] 王海涛[1] 朱起之[1] 童俊容[1] 张虹[1] 

机构地区：[1]广州军区广州总医院肾内科,广东广州510010

出　　处：《中国中西医结合急救杂志》2006年第3期159-161,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：广东省中医药局科研基金资助项目(1040138)

摘　　要：目的:观察序贯结肠透析对早中期慢性肾功能衰竭(肾衰)患者的疗效。方法:对142例早中期慢性肾衰患者进行序贯结肠透析治疗,并根据其中医辨证分型具体用药,观察其临床症状;同时选取63例慢性肾衰患者作为对照,给予低蛋白饮食+必需氨基酸。观察两组治疗前后血肌酐、尿素氮、尿酸、内生肌酐清除率、K+、N a+、C l-、C a2+、P3-以及中分子物质水平的变化。结果:142例患者中,各种慢性肾衰的临床症状明显好转,血肌酐〔(443.6±73.5)μm o l/L比(283.5±38.7)μm o l/L〕、尿素氮〔(15.3±4.5)mm o l/L比(8.6±3.3)mm o l/L〕、尿酸〔(512.6±86.5)μm o l/L比(243.1±33.6)μm o l/L〕及中分子物质(0.44±0.06比0.32±0.04)水平均显著下降,内生肌酐清除率〔(9.87±3.31)m l/m in比(15.60±4.63)m l/m in〕明显升高,与对照组比较差异也有显著性。两组治疗前后电解质无明显变化。结论:序贯结肠透析对早中期慢性肾衰患者疗效显著,可有效延缓早中期慢性肾衰的进展。Objective： To observe the effect of sequential colon dialysis in patients with chronic renal failure （CRF） in early and medium stage. Methods.. One hundred and forty-two CRF patients in early and medium stage were treated with sequential colon dialysis and traditional Chinese medicine according to traditional Chinese medical syndrome differentiation and typing, and clinical syndromes were observed. Sixty-three patients with CRF were selected as controls treated with low protein diet plus essential amino acids. The serum levels of blood urea nitrogen （BUN）, creatinine （Cr）, uric acid （UA）, the creatinine clearance rate （CCr）, electrolyte and medium molecular substance （MMS） were measured before and after treatment. Results： The clinical symptoms of the 142 patients were improved, the serum levels of BUN, Cr, UA and MMS were decreased significantly （BUN ： （15.3 5±4. 5） mmol/L vs. （8.6 5±3.3 ） mmol/L; Cr ： （443.6±73.5）μmol/L vs. （283.5±38.7）μmol/L; UA： （512.6±86.5）μmol/L vs. （243.15±3.6）μmol/L; MMS： 0.44±0.06 vs. 0.32±0. 04[, and CCr increased markedly C（9.87±3.31）ml/min vs. （15.60±4.63）ml/min]. The difference between treatment group and control group was significant. The changes in electrolyte levels were not significant before and after treatment in both groups. Conclusion： Sequential colon dialysis has obviously curative effects on CRF patients in early and medium stage, and could ameliorate the develope of CRF in early and medium stage.

关 键 词：序贯结肠透析 中药 肾功能衰竭 慢性 

分 类 号：R692.5[医药卫生—泌尿科学]