乙肝妊娠患者孕早期绒毛姐妹染色单体交换率的研究  

The Study on Chorion Sister Chrimatid Exchange (SCE) Rate of the Early Pregnant Women with Hepatitis B

作　　者：岳淑芬[1] 宋芳[1] 赵紫薇[1] 郝奋[1] 

机构地区：[1]包头医学院组胚教研室,内蒙古包头014010

出　　处：《包头医学院学报》2006年第2期128-129,共2页Journal of Baotou Medical College

基　　金：包头医药卫生资助项目(编号2004R2322-8)

摘　　要：目的:探讨乙肝患者体内遗传物质的损伤情况。方法:选择正常对照组20例,单纯HBsAg(+)增高组16例,乙肝组16例,乙肝恢复组10例,HBsAg、抗HBe、抗HBc三阳组12例,脂肪肝组16例,做孕早期绒毛姐妹染色单体交换(SCE)率的检测。结果:单纯HBsAg(+)增高组、乙肝组自发和诱发SCE逐步增高,且与对照组间均有显著差异;乙肝恢复组较乙肝组SCE下降;其他肝病患者较乙肝组SCE均较低。结论:乙肝妊娠妇女体内出现DNA损伤及修复功能障碍。Objective： To investigate the damage extent of germ plasm in the patients with hepatitis B. Methods： To detect the chofion SCE rate of the control groups, including 20 normal pregnant women, Group 1 of 16 with increased HBsAg, Group 2 of 16 with hepatitis B, Group 3 of 10 with recovered hepatitis B, Group 4 of 12 with HBsAg（＋）, HBeAb（＋）, HbcAb（＋） and Group 5 of 16 with fatty liver. Results： Spontaneous and induced SCE rate increased gradually in control group, Group 1 and Group 2. At the same time, there were significantly differences among the three groups. In Group 3 and the other two groups, SCE rate all decreased. Conclusion： DNA damnification and repair obstruction appeared in the pregnant women with hepatitis B.

关 键 词：乙肝 孕早期 绒毛 姐妹染色单体交换 

分 类 号：R714.2[医药卫生—妇产科学]