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机构地区:[1]包头医学院组胚教研室,内蒙古包头014010
出 处:《包头医学院学报》2006年第2期128-129,共2页Journal of Baotou Medical College
基 金:包头医药卫生资助项目(编号2004R2322-8)
摘 要:目的:探讨乙肝患者体内遗传物质的损伤情况。方法:选择正常对照组20例,单纯HBsAg(+)增高组16例,乙肝组16例,乙肝恢复组10例,HBsAg、抗HBe、抗HBc三阳组12例,脂肪肝组16例,做孕早期绒毛姐妹染色单体交换(SCE)率的检测。结果:单纯HBsAg(+)增高组、乙肝组自发和诱发SCE逐步增高,且与对照组间均有显著差异;乙肝恢复组较乙肝组SCE下降;其他肝病患者较乙肝组SCE均较低。结论:乙肝妊娠妇女体内出现DNA损伤及修复功能障碍。Objective: To investigate the damage extent of germ plasm in the patients with hepatitis B. Methods: To detect the chofion SCE rate of the control groups, including 20 normal pregnant women, Group 1 of 16 with increased HBsAg, Group 2 of 16 with hepatitis B, Group 3 of 10 with recovered hepatitis B, Group 4 of 12 with HBsAg(+), HBeAb(+), HbcAb(+) and Group 5 of 16 with fatty liver. Results: Spontaneous and induced SCE rate increased gradually in control group, Group 1 and Group 2. At the same time, there were significantly differences among the three groups. In Group 3 and the other two groups, SCE rate all decreased. Conclusion: DNA damnification and repair obstruction appeared in the pregnant women with hepatitis B.
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