伊曲康唑巩固疗法降低花斑癣复发率的临床研究  

A comparative clinical study of the consolidation treatment of itraconazole in pityriasis versicolor

作　　者：王亚平[1] 刘金昌[1] 刘良传[1] 滕蔚[1] 

机构地区：[1]青岛市立医院皮肤科,山东青岛266011

出　　处：《临床皮肤科杂志》2006年第6期376-377,共2页Journal of Clinical Dermatology

基　　金：中华医学会皮肤性病学皮肤科研究基金资助项目(2002~2003)

摘　　要：目的:探讨一种能够降低花斑癣复发率的有效治疗方案。方法:将初诊的花斑癣患者按就诊时间分为两组,均口服伊曲康唑0.2g,每日1次,连续服药7d。7d后对照组停药观察,试验组则继续服用伊曲康唑,每月口服0.2g1次,共6个月。两组患者皆每月复诊1次,共6次。结果:试验组99例患者复发率为1.01%,治愈率为85.86%。对照组95例患者复发率为17.89%,治愈率为64.21%。经卡方检验两组患者的复发率及治愈率相比,差异均有极显著性(χ2=16.4195,P=0.0001和χ2=12.2013,P=0.0005)。结论:巩固治疗方案能在近期内降低花斑癣复发率,同时提高花斑癣的治愈率。Objective： To investigate an effective treatment plan to reduce the recurrence rate of pityriasis versicolor. Methods： The patients with pityriasis versicolor were allocated to two groups at random. All patients orally took itraconazole 0.2 g once daily for 7 days. As prophylactic treatment 0.2 g itraconazole was continually given once a month for 6 months in the test group. As control nothing was continually used. The therapeutic effects were evaluated once a month for 6 months. Results： The clinical recurrence rate and cure rate in the test group were 1.01% and 85.86% respectively, while it were 17.89% and 64.21% in control group. There were statistically significant differences in above-mentioned two rates between the two groups （P= 0.000 1, P = 0.000 5）. Conclusion： The consolidation treatment in pityriasis versicolor can reduce the recurrence rate and increase the cure rate.

关 键 词：花斑癣 伊曲康唑 复发率 

分 类 号：R756.9[医药卫生—皮肤病学与性病学]