干燥综合征患者唾液pH值、电解质测定的诊断意义初步探讨  

Measurement of pH and electrolytes of saliva for the diagnosis of Sjgren syndrome

作　　者：王万春 吴宁[2] 王凤华[2] 吴迎涛 刘丰海[2] 

机构地区：[1]青岛市口腔医院,266003 [2]青岛市市立医院

出　　处：《实用口腔医学杂志》2006年第3期408-411,共4页Journal of Practical Stomatology

摘　　要：目的:探讨唾液生化指标测定对初步诊断干燥综合征的临床价值。方法:分为干燥综合征病变组和正常对照组,吐取法采集混合唾液,测定唾液pH值、Na+、K+浓度,计算Na+/K+,Na+、K+单位时间分泌总量。t检验统计分析。结果:干燥综合征病变组唾液Na+、K+浓度、Na+/K+明显高于正常对照组,与正常对照组相比,病变组K+单位时间分泌总量明显下降,pH值显著降低。Na+浓度、Na+/K+敏感性、特异性均较高,pH值特异性较高,K+单位时间分泌总量敏感性、特异性一般。结论:唾液检查是一种简便、准确、无创的检查手段,干燥综合征患者唾液pH值、电解质具有特征性,其综合评定对初步筛选干燥综合征有一定临床价值。Objective：To define the reference values of several salivary variables for the diagnosis of SjSgren syndrome （SS）. Methods：Mixed saliva was collected by standard proceduer. Sodium, potassium concentration, sodium-potassium ratio,total value of sodium and potassium secretion per minute and pH of the saliva samples in 40 patients with SS and 40 healthy controls were measured by automatic biochemical instrument ISE900 and pH meter, The subjects were divided according to the European classification criteria for diagnosis of SS and normal controls. Independent-sample t test were used for statistic analysis, Results ：The salivary concentrations of sodium, potassium and sodium-potassium ratio were significantly elevated and the tolal value of potassium per minute and pH were significantly reduced in patients with SS（ P〈0.5 or P〈0.01 ）. The specificity and sensitivity of salivary sodium concentration for the diagnosis were 92.5% and 90% , those of sodium-potassium ratio 97.5% and 92.5% , pH 92.5% and 82.5%, respectively. Conclusion： Measurement of pH and electrolytes of saliva may be recommended as a diagnostic test for the diagnosing Sjǒgren syndrome.

关 键 词：干燥综合征 唾液 PH 电解质 

分 类 号：R593.2[医药卫生—内科学]