Preparation and Characterization of Copolymer Micelles Formed by Poly(ethylene glycol)-Polylactide Block Copolymers as Novel Drug Carriers  

作　　者：姜维 王运东 甘泉 张建铮 赵秀文 费维扬 贝建中 王身国 

机构地区：[1]State Key Laboratory of Chemical Engineering, Tsinghua University [2]School of Chemical Engineering, Queen’s University Belfast, Belfast BT9 5AG, UK [3]Institute of Chemistry, Chinese Academy of Sciences

出　　处：《过程工程学报》2006年第2期289-295,共7页The Chinese Journal of Process Engineering

基　　金：National Natural Science Foundation of China (No.29836130)

摘　　要：Diblock copolymer poly(ethylene glycol) methyl ether–polylactide (MePEG–PLA) micelles were prepared by dialysis against water. Indomethacin (IMC) as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration (CMC) of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEGPLA micelles and IMC loaded MePEGPLA micelles in a number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. The observation with transmission electron microscope and scanning electron microscope showed that the appearance of MePEGPLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18% (ω). The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.Diblock copolymer poly（ethylene glycol） methyl ether-polylactide （MePEG-PLA） micelles were prepared by dialysis against water. Indomethacin （IMC） as a model drug was entrapped into the micelles by dialysis method. The critical micelle concentration （CMC） of the prepared micelles in distilled water investigated by fluorescence spectroscopy was 0.0051 mg/mL which is lower than that of common low molecular weight surfactants. The diameters of MePEG-PLA micelles and IMC loaded MePEG-PLA micelles in a number-averaged scale measured by dynamic light scattering were 52.4 and 53.7 nm respectively. The observation with transmission electron microscope and scanning electron microscope showed that the appearance of MePEG-PLA micelles was in a spherical shape. The content of IMC incorporated in the core portion of the micelles was 18% （ω）. The effects of the synthesis method of the copolymer on the polydispersity of the micelles and the yield of the micelles formation were discussed.

关 键 词：聚乙二醇 聚交酯 嵌段共聚 聚合物 药物担体 

分 类 号：R944.1[医药卫生—药剂学]