制霉菌素口腔粘附片的研制及粘附性考察  

Preparation of Nystatin Buccal Adhesive Tablets and Adhesiveness Study

作　　者：邹阳[1] 黄华[1] 

机构地区：[1]重庆医科大学药剂学教研室,重庆市400016

出　　处：《中国药房》2006年第11期815-817,共3页China Pharmacy

摘　　要：目的:研制制霉菌素口腔粘附片,并考察其生物粘附性。方法:以卡波姆(CP)、羟丙基甲基纤维素(HPMC)为粘附材料和缓释骨架制备不同处方配比的制霉菌素口腔粘附片,测定其粘附力、粘附时间、溶胀百分比和表面pH值。结果:不同处方配比制备的粘附片生物粘附性差异较大,以CP∶HPMC为1∶1的处方制备的粘附片效果较好。结论:成功制备了制霉菌素口腔粘附片,其可用于进一步的体内、外研究。OBJECTIVE： To prepare nystatin buccal adhesive tablets and to study their properties of bioadhesion. METHODS： Nystatin buccal adhesive tablets of different formula matching ratio were prepared with carbomer （CP） and hydroxy- propyl methyl cellulose （HPMC） as adhesive material and slow release framework, and the adhesive power, duration of adhesion, swelling percentage and surface pH data of which were determined. RESULTS： There were great differences regarding bioadhesive properties among the adhesive tablets that of different formula matching ratio, the adhesive tablets that prepared in a formula matching ratio of 1：1 between CP to HPMC were of the best adhesiveness outcome. CONCLUSIONS： The buccal adhesive tablets were prepared successfully, and which can be used for the further study both in vivo and in vitro.

关 键 词：制霉菌素 口腔粘附片 粘附性 

分 类 号：R288.2[医药卫生—中药学]