酮洛芬巴布剂的制备及其经皮体外渗透试验  

Preparation and Per Cutem Permeability Test of Ketoprofen Poultice

作　　者：车晓侠[1] 余李敏[2] 席枝侠[1] 

机构地区：[1]西安交通大学第二医院,西安市710004 [2]沈阳药科大学,沈阳市110016

出　　处：《中国药房》2006年第11期826-828,共3页China Pharmacy

摘　　要：目的:研究酮洛芬巴布剂的最优处方并考察其影响因素。方法:采用正交试验法设计处方,拉力机测定粘着强度,利用Franz扩散池考察体外经皮渗透性。结果:筛选出最优处方,其粘着强度为40N,稳态流量为9·72μg/(cm2·h)。结论:建立的巴布剂制备工艺合理、稳定,粘着强度和透皮效果为其主要质量影响因素。OBJECTIVE： To optimize the matrix formulation of ketoprofen cataplasm and to investigate its influencing factors. METHODS： Orthogonal design was used to design formulations,adhesive stress was tested with the tension meter and the per cutem permeability in vitro was studied using the franz diffusion cell. RESULTS： The optimal poultice was acquired with adhesive stress at 40 N and steady permeation flux at 9.72 μg/ （cm^2 · h） . CONCLUSION： The established preparation technique of poultice is stable and feasible, and its leading influencing factors are adhesive stress and transdermal effects.

关 键 词：酮洛芬 巴布剂 正交试验 粘着强度 稳态流量 

分 类 号：TQ460.6[化学工程—制药化工] R971.1[医药卫生—药品]