我院3种非发酵革兰阴性杆菌耐药谱4年变迁  

Changes of Antibiotic Resistance Spectra of 3 Non-fermental G^- Bacteria in Recent 4 Years in Our Hospital

作　　者：骆军[1] 魏衍超[1] 林红燕[1] 

机构地区：[1]广州医学院附属第二医院,广州市510260

出　　处：《中国药房》2006年第11期839-841,共3页China Pharmacy

基　　金：广东省社会发展领域科技计划项目(53051)

摘　　要：目的:分析我院4年来3种非发酵革兰阴性杆菌耐药谱的变化,为临床合理选用抗菌药物提供依据。方法:采用K-B纸片扩散法检测分析2001年7月~2005年6月我院临床标本中分离出的铜绿假单胞菌、鲍曼不动杆菌、嗜麦芽寡养单胞菌对常用抗生素的耐药性,数据结果输入WHONET5软件进行统计分析。结果:4年检出铜绿假单胞菌598株,鲍曼不动杆菌281株、嗜麦芽寡养单胞菌209株。对铜绿假单胞菌耐药率低于30%的有头孢他定、阿米卡星、头孢哌酮/舒巴坦、亚胺培南等抗生素;鲍曼不动杆菌对亚胺培南敏感率较高,对其它常用抗生素耐药率均超过50%;对嗜麦芽寡养单胞菌耐药率较低的有复方新诺明和氧氟沙星。结论:非发酵菌在我院耐药率高,常表现为多重耐药,监测非发酵菌的感染及其耐药性变化,对指导合理应用抗菌药物有重要意义。OBJECTIVE： To study the change of antibacterial resistance spectra of 3 non- fermental G bacteria in our hospital during recent 4 years, so as to guide the rational use of antibacterial. METHODS： Pseudomonas aeruginosa, acinetobacter baumanii, stenotrophomonas maltophilia were isolated from clinical samples in our hospital from July 2001 to June 2005, the susceptibility of these isolates were tested by Kirby - Bauer agar diffusion method , data were analyzed by WHONETS. RESULTS： 598 strains of P. aeruginosa, 281 strains of A.baumanii and 209 strains of S. maltophilia were obtained during 4 years.Now the resistance rates of ceftazidime, amikacin, cefoperazone/ sulbactam and imipenem to P. aeruginosa were lower than 30% ;A.baumanii were sensitive to imipenem, the other antibiotic resistance rates were more than 50% ; The antibiotic resistance rate of S. maltophilia to ofloxacin and trimethoprim/ sulfamethoxazole was relatively lower.CONCLUSIONS： The antibiotic resistance rates of non - fermental G^- bacteria are high and display multiple - resistant. It＇s important to monitor the antibiotic resistance periodically to guide clinical antibiotics use.

关 键 词：非发酵革兰阴性杆菌 耐药性 抗菌药物 

分 类 号：R951[医药卫生—药学]