^(99m)TcN核标记的新型心肌灌注显像剂的研究  

Novel ^(99m)Tc-nitride Heterocomplexes as Potential Myocardial Perfusion Imaging Agents

作　　者：楚进锋[1] 孔德靖[2] 李彬[2] 王学斌[2] 陆洁[2] 王金城[3] 米宏志[3] 赵建冬[3] 

机构地区：[1]北京化工大学理学院,北京100029 [2]北京师范大学化学系,北京100875 [3]北京安贞医院核医学科,北京100029

出　　处：《高等学校化学学报》2006年第6期1016-1019,共4页Chemical Journal of Chinese Universities

摘　　要：通过配体交换反应制备了[99mTcN(PNP5)(DEDC)]+和[99mTcN(PNP5)(DPODC)]+两种新配合物,其放化纯度均大于90%.生物性能研究结果表明:两种配合物在小鼠心肌中的初始摄取高,肝、肺等非靶组织清除快,靶/非靶比高,有利于早期心肌显像.其中,[99mTcN(PNP5)(DEDC)]+在小鼠中的性质较优,且其在狗体内的性质接近99mTc-tetrofosm in,有望成为一种新型心肌灌注显像剂.To develop a new potential myocardial imaging agent, [^99mTcN（PNP5）（DEDC）] ^＋ and [ ^99mTcN（ PNP5 ） （DPODC） ] ^＋ were prepared through ligand exchange reaction. Their radiochemical purities were over 90%. The results of biodistribution in mice indicate that they possessed a high myocardial uptake, rapid clearance from non-target tissues and good ratios of target to non-target. And [^99mTcN（PNP5）. （DEDC） ]^＋ is superior. SPECT imaging in dog shows that its properties were similar to those of ^99m Tctetrofosmin. Based on its promising characters, it may be suitable for myocardial perfusion imaging.

关 键 词：^99TcN核 心肌灌注显像剂 生物分布 

分 类 号：O615.4[理学—无机化学]