人参皂苷Rb_1在大鼠体内的药物代谢研究  

In Vivo Rat Metabolism Studies of Ginsenoside-Rb_(1)

作　　者：杨柳[1] 许舜军[2] 曾星[1] 巫志峰[1] 邓远辉[1] 刘奕明[1] 邓时贵[1] 欧润妹[1] 

机构地区：[1]广州中医药大学附属广东省中医院,广州510120 [2]中国药科大学生药研究室,南京210038

出　　处：《高等学校化学学报》2006年第6期1042-1044,共3页Chemical Journal of Chinese Universities

基　　金：国家'八六三'计划(批准号:2002AA2Z341B)资助

摘　　要：The major metabolites of ginsenoside-Rb1 in rats urine were described.Urine samples were collected before and after 24 h of single oral administration of 150 mg and intravenous administration of 60 mg Rb1 to four rats,respectively.The samples were purified by SPE column and then were analyzed by liquid chromatography-ESI-mass spectrometry for potential metabolites.Parent drug and its fourteen metabolites were identified in rat urine based on the comparison of total ion chromatograms of the blank with the metabolic urine as well as mass spectra.Its main metabolic pathways and possible structures are analyzed in detail.The major metabolites of ginsenoside-Rb1 in rats urine were described. Urine samples were collected before and after 24 h of single oral administration of 150 mg and intravenous administration of 60 mg Rb1 to four rats, respectively. The samples were purified by SPE column and then were analyzed by liquid chromatography-ESI-mass spectrometry for potential metabolites. Parent drug and its fourteen metabolites were identified in rat urine based on the comparison of total ion chromatograms of the blank with the metabolic urine as well as mass spectra. Its main metabolic pathways and possible structures are analyzed in detail.

关 键 词：人参皂苷RB1 液相色谱/飞行时间串联质谱 药物代谢 

分 类 号：O657[理学—分析化学]