用于研究病毒唑作用机理的光敏探针的设计与合成  

Design and Synthesis of Photolabeling Probes for the Study of Antiviral Mechanism of Ribavirin

作　　者：朱洵[1] 曲凡歧[2] 

机构地区：[1]北京大学天然药物与仿生药物国家重点实验室 [2]武汉大学化学与分子科学学院,武汉430072

出　　处：《高等学校化学学报》2006年第6期1062-1065,共4页Chemical Journal of Chinese Universities

摘　　要：对用于研究病毒唑作用机理的光敏探针进行了设计,并以四乙酰核糖化合物和3-溴-1,2,4-三唑-5-酰甲酯化合物为原料进行合成实验,得到光敏探针化合物5-叠氮基-1-(β-呋喃核糖基)-1,2,4-三唑-3-酰胺和3-叠氮基-1-(β-呋喃核糖基)-1,2,4-三唑-5-酰胺.采用IR,MS和1H NMR等技术对化合物的结构进行了表征,同时对探针分子的设计和结构判定进行了探讨.The photolabeling probes for the study of antiviral mechanism of ribavirin were designed, and the synthesis experiments were carried out by using 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose and methyl 3-bromo- 1,2,4-triazole-5-carboxylate as the raw materials. Two photolabeling probes for the study of antiviral mechanism of ribavirin, 5-azido-l-（β-ribofuranosyl）-I ,2,4-triazole-3-carboxamide and 3-azido-1-（β-ribofuranosyl）- 1,2,4-triazole-5-carboxamide were synthesized, and characterized by IR, MS and ^1H NMR, etc.. The design of the photolabeling probes and their structures were discussed.

关 键 词：病毒唑 光敏探针 三唑叠氮化合物 设计 合成 

分 类 号：O627.27[理学—有机化学]