丁丙诺啡舌下片合并东莨菪碱、异丙嗪静脉注射对认知功能的影响  

EFFECT OF INTRAVENOUS ABUSE OF BUPRENORPHINE TABLETS,SCOPOLAMINE AND PROMETHAZINE ON COGNITIVE FUNCTION

作　　者：周旭辉[1] 张登科[1] 邓慧琼[1] 张雪辉[2] 邱进平[2] 谌红献[1] 向小军[1] 王绪轶[1] 郝伟[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]长沙市公安局强制戒毒所,长沙410011

出　　处：《中国药物依赖性杂志》2006年第2期35-39,共5页Chinese Journal of Drug Dependence

基　　金：国家重点基础研究发展计划(973)课题(2003CB515400);国家自然科学基金(30370522)资助

摘　　要：目的:了解丁丙诺啡舌下片合并东莨菪碱、异丙嗪静脉注射(简称“1+1”)对认知功能的影响。方法:对60例“1+1”滥用者、60例海洛因依赖对照者采用韦氏记忆量表、Stroop测验以及威斯康星卡片分类测验工具,分别对其记忆、注意和执行功能进行测试。结果:“1+1”滥用组的记忆商数(76·78±s18·62)明显低于海洛因对照组(95·67±s14·62),尤其以视觉再认、图片回忆、视觉再生、触摸记忆、理解记忆和背诵数目为甚(P<0·001);“1+1”滥用组的Stroop(C、CW)总时间、ST-C中不正确数和纠正数高于海洛因对照组,差异有显著性(P<0·01);“1+1”滥用组的WCST-M测验的分类错误数、持续错误总数高于海洛因对照组,正确分类个数低于对照组,差异有统计学意义(P<0·05)。结论:“1+1”滥用者在使用上述药物后,即使未再使用海洛因,但认知损害仍在继续加重,主要表现为大脑记忆、注意和执行功能方面存在不同程度的损害。Objective： To investigate the effect of intravenous abuse of buprenorphine tables, scopolamine and promethazine, which was abbreviated to be ＂1 ＋ 1＂ abuse in China, on the cognitive function of its abusers. Methods： Cognitive function of 60 ＂1 ＋ 1＂ abusers and 60 heroin addicts as control was assessed with a battery of neuropsychological evaluation instruments in Changsha, China. The tools included Wechsler Memory Scale - revised test （WMS）, Stroop Test （C, CW） and Modified Wisconsin Card Sorting Test （WCST - M）. Results： The memory quotient and the scores on such factors as vision recognition, picture recall, design reproduction, touch memory, story recall as well as digit span of the ＂1 ＋ 1＂ abusers （76.78±s 18.62） were significantly lower than those of the heroin addicts control group （95.67±s 14.62）, P 〈 0.001. There was significant difference between the two groups in the time spent in Stroop test （C, CW）, the number of errors and rectification in Stroop - C test, with the ＂1 ＋ 1＂ abusers spending more time in Stroop test （C, CW）, and having more errors and rectification in Stroop - C test. （P 〈 0.01） Furthermore, the ＂1 ＋ 1＂ abusers had more scores in total, persistent errors, and lower number of categories in WCST, showing statistical significant difference （P 〈 0.05）. Conclusion： Certain cognitive dysfunction, such as memory, attention and executive function is observed in the ＂1 ＋ 1＂ abusers in our objects. The impairment of cognitive function, which has been caused by heroin abuse, continue to aggravate, even if the ＂1 ＋ 1＂ abusers only use the intravenous form of buprenorphine tables, scopolamine and promethazine, while keeping abstinence to heroin.

关 键 词：丁丙诺啡 东莨菪碱 异丙嗪 静脉注射 药物滥用 认知功能 

分 类 号：R996[医药卫生—毒理学] R971.92[医药卫生—药学]