即刻早基因ZENK的基因功能及其应用进展  

Proceedings of Immediate Early Gene ZENK in Gene Function and Application

作　　者：方亲亲[1] 吴孝兵[1] 

机构地区：[1]安徽师范大学生命科学学院,安徽芜湖241000

出　　处：《安徽师范大学学报（自然科学版）》2006年第3期272-275,280,共5页Journal of Anhui Normal University(Natural Science)

基　　金：国家自然科学基金(30470244;30270213);安徽省优秀青年基金(04043049);安徽省学术与技术带头人专项基金;重要生物资源保护与利用安徽省重点实验室基金

摘　　要：即刻早基因ZENK是核基因组内编码转录因子的单拷贝基因,它受多种胞外信号,如血清、生长因子、细胞因子和激素的作用在不同类型细胞内迅速、大量表达.ZENK蛋白通过C2H2型锌指识别靶基因启动子中的GC丰富序列并发生作用,从而调控靶基因的转录.ZENK基因参与细胞生长、分化、发育的调控,而且其在大脑的诱导表达与动物的学习、记忆密切关联.另有研究显示,ZENK具有很高的进化保守性,可以作为新的分子标记运用于分子系统学研究.Immediate early gene ZENK is a single copy nuclear gene. It encodes a nuclear transcription factor. The gene is rapidly and transiently activated in many different cell types by a variety of extracellular signals such as serum, growth factors, cytokines, and hormones. ZENK protein recognizes and binds to GC-rich sequences in the promoter of target genes with the DNA-binding domain, and regulates their transcription. ZENK is involved in the regulation of cell growth, differentiation and development. Its expression in brain pivotally connected with animal＇s learning and memory. Recent studies show that ZENK has highly evolutional conservation, which implies that it can be applied in molecular systematic studies as a new molecular marker.

关 键 词：即刻早基因 ZENK 神经元可塑性 进化保守性 

分 类 号：Q7[生物学—分子生物学]