人肝组织病变及热凝固导致组织光学特性的变化  

Pathological Changes and Thermal Coagulation of Human Liver Tissue Induced Changes in the Optical Properties of Liver Tissue at KTP/YAG Laser in vitro

作　　者：魏华江[1] 邢达[1] 巫国勇[2] 谷怀民[1] 鲁建军[2] 何博华[3] 

机构地区：[1]华南师范大学激光生命科学研究所,广东广州510631 [2]中山大学第一附属医院心胸外科,广东广州510080 [3]广东药学院临床医学系外科,广东广州510224

出　　处：《中国激光》2006年第6期852-856,共5页Chinese Journal of Lasers

基　　金：国家973前期专项基金(2002CCC00400);国家自然科学基金(60378043);广东省自然科学基金(015012)资助项目

摘　　要：研究了人肝的病变及热凝固的肝组织对532 nm和1064 nm激光的光学特性的变化。实验采用双积分球测量系统以及运用生物组织的反向倍增(IAD)光学模型。结果表明,正常肝组织对532 nm和1064 nm的吸收系数显著地较肝肿瘤组织要大;正常肝和肝肿瘤组织热凝固后对532 nm的吸收系数都显著地增大,正常肝组织热凝固后对1064 nm的吸收系数显著减小。而肝肿瘤组织热凝固后对1064 nm的吸收系数却显著地增大。正常肝组织对532 nm和1064 nm的散射系数都显著地较肝肿瘤组织要小,正常肝和肝肿瘤组织热凝固后散射系数都显著地增大。正常肝组织对532 nm和1064 nm的各向异性因子都明显地较肝肿瘤组织要大,正常肝和肝肿瘤组织热凝固后其各向异性因子都明显地减小。Pathological changes and thermal coagulation of human liver tissue induced changes of the optical properties of liver tissue at 532 and 1064 nm wavelengths of laser in vitro. The measurements were performed using a double integrating-sphere setup, and the optical parameters were assessed from these measurements using the inverse adding-doubling method （IAD）. The results of measurement showed that the absorption coefficients of normal liver tissues at 532 and 1064 nm are significantly bigger than those of liver tumors at the same wavelength respectively. When liver tissues were coagulated by heat, the absorption coefficients of normal and tumorous liver tissues of thermal coagulation at 532 nm significantly increase, the absorption coefficient of normal liver tissues of thermal coagulation at 1064 nm significantly decreases, and the absorption coefficient of liver tumors of thermal coagulation at 1064 nm significantly increases. The scattering coefficients of normal liver tissue at 532 and 1064 nm are significantly smaller than those of liver tumors at the same wavelength. When liver tissues were coagulated by heat, the scattering coefficients of normal and tumorous liver tissue of thermal coagulation significantly increase. The anisotropy factors of normal liver tissue at 532 and 1064 nm are obviously bigger than those of liver tumors at the same wavelength respectively. When liver tissues were coagulated by heat, the anisotropy factors of normal and tumorous liver tissue of thermal coagulation at 532 and 1064 nm obviously decrease.

关 键 词：医用光学与生物技术 组织光学 光学特性 人肝组织 KTP/YAG激光 病变 热凝固 

分 类 号：R318.51[医药卫生—生物医学工程]