全麻下超快速脱毒复合洛菲西定治疗海洛因依赖  

THE EFFECT OF LOFEXIDINE FOR THE MANAGEMENT OF HEROIN ADDICTS AT ULTRA-RAPID OPIOID DETOXIFICATION UNDER GENERAL ANESTHESIA

作　　者：何日辉[1] 肖晓山[1] 卓福镇[1] 邓栋梁[1] 张云[1] 

机构地区：[1]广东省第二人民医院麻醉科,广州510317

出　　处：《中国药物依赖性杂志》2006年第1期27-30,共4页Chinese Journal of Drug Dependence

摘　　要：目的探讨全麻下超快速脱毒(UROD)复合洛菲西定治疗海洛因依赖的效果。方法选择60例海洛因依赖者,随机分成两组。对照组行常规UROD,试验组在此基础上,术前晚口服洛菲西定0.4mg,术中再给予1.6mg。对两组病人围术期腹泻,丙泊酚用量及戒断症状评分进行评估。结果与对照组相比,试验组的丙泊酚用量(P<0.001),术后24h内腹泻的发生率(P<0.01),术后24h时主观戒断症状的评分(P<0.001)和客观戒断症状评分(P<0.05)的差异均有显著性。结论UROD复合洛菲西定用于海洛因依赖者脱毒,可以明显减轻戒断症状并降低费用,值得推广。Objective ：To determine the effect of lofexidine on the treatment of heroin addicts with UROD（ Ultra- rapid opioid detoxification under general anesthesia）. Methods： Sixty heroin addicts were randomly divided into two groups. One group was treated with UROD only and the other was treated with UROD and lofexidine which was given before （0. 4 mg） Postural hypotension, perioperative diarrhea, the of the two groups Were assessed by one person. dosage and during （1.6 mg）the treatment of UROD. of propofol and the score of withdrawal syndrome Results：Compared with the UROD alone treatment group, the mixture treatment group used less propofol（ P 〈0. 001 ） with lower occurrence of diarrhea （P 〈0. 01 ） within 24 h after UROD and lower subjective and objective scores of withdrawal（ P 〈0. 001, P 〈0. 05 ）at 24 h of UROD. Conclusion： Treatment with UROD and lofexidine can reduce the dosage of propofol and alleviate withdrawal syndromes.

关 键 词：洛菲西定 超快速脱毒 全麻 丙泊酚 戒断症状 腹泻 

分 类 号：R595.5[医药卫生—内科学] R614.2[医药卫生—临床医学]