环氧合酶-2在毛囊皮脂腺单位的表达及其意义  

Expression and significance of COX-2 in pilosebaceous unit

作　　者：徐远旭[1] 杨恬[1] 黄恩毅[2] 杨力[2] 向明明[3] 

机构地区：[1]第三军医大学基础医学部细胞生物学教研室,重庆400038 [2]重庆大学生物工程学院,重庆400044 [3]第三军医大学西南医院皮肤科重庆市皮肤性病研究所,重庆400038

出　　处：《第三军医大学学报》2006年第11期1170-1172,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目(30471568)~~

摘　　要：目的研究环氧合酶-2(cyc looxygenase-2,COX-2)在成年大鼠毛囊皮脂腺单位中的表达模式。方法用RT-PCR、免疫组织化学技术和原代干细胞培养技术观察COX-2在毛囊皮脂腺单位的表达情况。结果成年大鼠毛囊皮脂腺单位中,bu lge(隆突)区弱表达,皮脂腺高表达,而毛球部未见表达。结论COX-2在正常成年大鼠皮脂腺中呈特异性的表达,并且它的表达模式联系毛囊干细胞从bu lge到皮脂腺迁移分化通路,提示COX-2在毛囊干细胞定向分化为皮脂腺细胞中可能起一定的作用。Objective To investigate the expression pattern of COX-2 in adult rat pilosebaceous unit. Methods The expression pattern of COX-2 was detected by RT-PCT, immunohistochemical staining and stem cell primary culture. Results COX-2 expression in pilosebaceous unit of adult rat showed strongly positive at sebaceous gland, positive in bulge region and negative in hair matrix. Conclusion COX-2 in adult rat sebaceous gland was strongly and specifically expressed. Based on the theory that the hair follicle stem cells can migrate and differentiate from bulge region to sebaceous gland, the expression patterns of COX-2 indicates that it may play an important role on orienting differentiation of hair follicle stem cells to sebocytes.

关 键 词：环氧合酶-2 毛囊皮脂腺单位 干细胞 

分 类 号：R322.994[医药卫生—人体解剖和组织胚胎学] R345[医药卫生—基础医学]