犬双侧迷走神经干切断术对胆道动力学的影响  

Effect of truncal vagotomy on biliary dynamics in dogs

作　　者：禹建峰[1] 李智华[1] 李晓武[1] 刘永康[1] 徐世荣[2] 

机构地区：[1]第三军医大学西南医院全军肝胆外科研究所中国人民解放军肝脏移植重点实验室,重庆400038 [2]重庆大学生物力学与组织工程教育部重点实验室,重庆400044

出　　处：《第三军医大学学报》2006年第11期1173-1175,共3页Journal of Third Military Medical University

基　　金：高等学校重点实验室访问学者基金资助项目(重庆大学校科字[2003]76)~~

摘　　要：目的探讨双侧迷走神经干切断术对胆道动力学的影响.方法禁食16～18 h（可自由饮水）,成年杂种犬麻醉后,实验组行膈肌水平双侧迷走神经干切断术加幽门成形术,对照组仅行幽门成形术.手术8周后,超声检查测定胆总管内径,并行Oddi括约肌测压（SO manometry,SOM）,最后取胆囊内胆汁肉眼观察.结果实验组胆总管内压明显升高,内径明显增粗,胆汁内全部出现絮状泥沙样沉淀;实验组SO 基础压（SOBP）明显升高,SO收缩幅度、频率及收缩时间未观察到显著性变化.结论膈肌水平双侧迷走神经干切断术致使SOBP明显提高,胆道动力学发生明显变化.Objective To explore the effect of truncal vagotomy on biliary dynamics in dogs. Methods After fasted for 18 h, 12 adult mongrel dogs underwent bilateral truncal vagotomy at the diaphragmatic level and pyloroplasty in the experiment group, and only pyloroplasty in the control group. All dogs were performed ultrasonograph to determine the size of the common bile duct （CBD） and sphincter of Oddi manometry （SOM） to detect biliary dynamics at postoperative 8 weeks, then the bile was collected from gallbladder for further analysis. Results In the experiment group, the CBD pressure, inner diameter of CBD, and SO basal pressure （SOBP） increased significantly, and sediments were found in the bile of all dogs, but SO amplitude （SOAP）, frequency and duration of SO phasic contraction did not change. Conclusion Bilateral truncal vagotomy at the diaphragmatic level leads to significant increase of SOBP, resulting in a great change of biliary dynamics.

关 键 词：迷走神经干切断术 ODDI括约肌 胆道动力学 

分 类 号：R322.48[医药卫生—人体解剖和组织胚胎学] R615[医药卫生—基础医学]