伊曲康唑在多器官功能障碍综合征患者侵袭性真菌感染中的应用  

Itraconazole against invasive fungal infection in patients of multiple organ dysfunction syndrome

作　　者：熊建琼[1] 邓朝霞[1] 张雷[1] 文亮[1] 谢先会[1] 

机构地区：[1]第三军医大学西南医院急救部ICU,重庆400038

出　　处：《第三军医大学学报》2006年第11期1260-1261,共2页Journal of Third Military Medical University

摘　　要：目的评价伊曲康唑注射液治疗多器官功能障碍综合征(mu ltip le organ dysfunction syndrom e,MODS)患者侵袭性真菌感染的疗效及副作用。方法以伊曲康唑注射液治疗临床确诊的MODS患者侵袭性真菌感染15例,评价伊曲康唑的疗效及副作用。结果痊愈12例,显效1例,好转1例,无效(死亡)1例。在治疗过程中,未观察到不良反应。结论伊曲康唑注射液是治疗MODS患者侵袭性真菌感染安全、疗效确切的药物,值得在临床上推广使用。Objective To evaluate the efficacy and safety of itraconazole injection in treatment of invasive fungal infection in the patients with multiple organ dysfunction syndrome. Methods Invasive fungal infection in 15 patients with multiple organ dysfunction syndrom day on the first two days, then once a day, for 8 to 14 results of chemical detection were recorded. Everyday Results The recovery rate, effective rate, and e was treated with 200 mg itraconazole injection, twice a days. During the treatment, the symptoms and signs, the fungus, sputum, stool smear or culture were performed. fungal clearance in this trial with itraconazole injection were 80% （ 12/15 ）, 86.7% （ 13/15 ）, and 86.7% （ 13/15 ） respectively. The side effect was not found. Conclusion Itraconazole injection is an effective and safe drug against invasive fungal infection in patients with multiple organ dysfunction syndrome.

关 键 词：伊曲康唑注射液 多器官功能障碍综合征 真菌感染 

分 类 号：R442.8[医药卫生—诊断学] R519.05[医药卫生—临床医学]