解毒活血法治疗胃癌前病变合并胃溃疡临床观察  

Clinical Observation of “Jiedu Huoxue Decoction”in Treating Precancerous Lesion of Gastric Cancer with Gastric Ulcer

作　　者：王志坤[1] 刘启泉[1] 刘晓辉[1] 张纨[2] 

机构地区：[1]河北省中医院消化内科,河北石家庄050011 [2]河北医科大学,2004级研究生河北石家庄050011

出　　处：《上海中医药杂志》2006年第5期23-24,共2页Shanghai Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科学研究计划项目(05012)

摘　　要：目的观察解毒活血法治疗胃癌前病变合并胃溃疡的临床疗效。方法将102例患者按随机对照的方法分为治疗组52例(采用以解毒活血法组方的颗粒剂治疗)和对照组50例(采用雷尼替丁加维酶素治疗),疗程均为3个月。主要观察治疗后患者胃镜及病理改变情况。结果治疗组胃溃疡有效率为94.23%,对照组为78.00%;治疗组肠上皮化生、异型增生以及肠上皮化生合并异型增生的治愈率分别为64.29%、56.25%、50.00%,对照组分别为33.33%、26.67%、12.50%,组间比较差异均有显著性意义(P<0.05)。结论解毒活血法对胃癌前病变合并胃溃疡有较好的临床疗效。Objective To observe the therapeutic effect of ＂Jiedu Huoxue Decoction＂ on precancerous lesion of gastric cancer （PLGC） with gastric ulcer （GU）.MCthods One hundred and two subjects were randomly divided into two groups： treatment group （52 cases） and control group（50 cases）, 52 cases in treatment group were given ＂Jiedu Huoxue Decoction＂ and those in control group were given Ranitidine and Weimeisu. After treatment, gastroscopes and pathological changes were observed in two groups. Results The cure rate of GU was 94.23% and 78.00% respectively; the cure rate of intestinal metaplasia was 64.29% and 33.33% respectively; the cure rate of dysplasia was 56.25% and 26.67% respectively; the cure rate of intestinal metaplasia with dysplasia was 50.00% and 12.50% respectively. It was shown that there was a significant difference between two groups（P 〈 0.05）. Conclusions ＂Jiedu Huoxue Decoction＂ is effective for PLGC with GU.

关 键 词：胃癌前病变 胃溃疡 中医药疗法 解毒活血 

分 类 号：R273[医药卫生—中西医结合]