抗早2号方对青春期雌性大鼠下丘脑-垂体-性腺轴的影响  

Effect of "Kangzao-Ⅱ Decoction"on hypothalamus-pituitary-sex gland Axis in Puberty Female Rats

作　　者：赵鋆[1] 朱敏华[1] 卓跃红[1] 易靖 

机构地区：[1]上海中医药大学附属曙光医院,上海200021

出　　处：《上海中医药杂志》2006年第5期44-45,共2页Shanghai Journal of Traditional Chinese Medicine

基　　金：曙光科技苗圃基金资助项目

摘　　要：目的研究抗早2号方对雌性青春期大鼠下丘脑-垂体-性腺轴的影响。方法观察高、中、低不同剂量抗早2号方对雌性青春期大鼠体重、对下丘脑、垂体、性腺和性器官组织结构以及对血清促黄体生成素(LH)水平的影响。结果抗早2号方对青春期雌性SD大鼠的体重增长有抑制作用,能明显抑制血清LH水平,使大鼠的子宫腺体发育延迟,卵巢内卵泡发育滞后,能使青春期雌性SD大鼠的下丘脑星形胶质细胞数量减少,体积缩小,使脑垂体分泌促卵泡生成素(FSH)和LH的嗜酸细胞减少。结论清热化痰中药抗早2号方能延缓雌性青春期大鼠下丘脑-垂体-性腺轴的启动发育进程。Objective To Study the Effect of ＂Kangzao-Ⅱ Decoction＂ on H-P-G Axis in Puberty Female Rats.Method To observe the influence of weight,the change of the structure in hypothalamus,pituitary,sex gland and sexual organs,the effect of luteinizing hormone （LH）with different dose Kangzao-Ⅱ Decoction.Results After 4 weeks medication,the gain weight,LH in serum,growth of uterus and ovary be slower significantly.Kangzao- Ⅱ Decoction can reduce asteroidal colloid cell in hypothalamus and acidophil cell in pituitary which secrete FSH and LH.Conclusion Kangzao-Ⅱ Decoction can decelerate the development of hypothalamus-pituitary-sex gland Axis in Puberty Female Rats.

关 键 词：抗早2号方 药理学 下丘脑 垂体 性腺 性器官 促黄体生成素 

分 类 号：R285[医药卫生—中药学]