损毁孤束核对电针足三里穴抗大鼠应激性胃溃疡作用的影响  

Electrolytic lesion of nucleus tractus solitarius weakens effects of electroacupuncturing Zusanli in treatment of gastric stress ulcer in rats

作　　者：黄碧兰[1] 黄华[2] 余良主[1] 秦灵芝[3] 

机构地区：[1]咸宁学院医学院生理学教研室,湖北省咸宁市437100 [2]华中科技大学同济医学院寄生虫教研室,湖北省武汉市430030 [3]咸宁学院医学院生物化学教研室,湖北省咸宁市437100

出　　处：《世界华人消化杂志》2006年第12期1210-1213,共4页World Chinese Journal of Digestology

基　　金：院科研基金资助项目;No.KY0539~~

摘　　要：目的:探讨孤束核(NTS)在电针(EA)足三里穴抗大鼠应激性胃溃疡中的作用.方法:健康♂SD大白鼠56只随机分为应激组、EA+应激组、NTS电损毁组、NTS假损毁组.通过脑立体定向仪电损毁大鼠孤束核,采用束缚-浸水制备大鼠应激性胃溃疡模型,分别测定各组胃黏膜损伤指数(UI)、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量.结果:与应激组比较,EA+应激组UI明显减少(t=9.5071,P<0.01),SOD活性升高(t=3.8729,P<0.01),MDA降低(t=2.3578,P<0.05).NTS电损毁组分别与假损毁组和EA+应激组比较UI提高(t=4.4223,7.2579,均P<0.01),SOD活性降低(t=3.5625,3.7242,均P<0.01),MDA含量升高(t=2.9045,2.4960,均P<0.05).结论:电损毁孤束核后,电针足三里穴对应激性胃黏膜损伤的保护作用减弱.AIM： To investigate the role of the nucleus tractus solitarius （NTS） in the treatment of gastric stress ulcer by electroacupuncturing （EA） Zusanli point. METHODS： The model of gastric stress ulcer was established by restraint and water immersion in 56 male Sprague Dawley rats. The rats were randomly divided into stress group, EA group, NTS electricity-damaged group and NTS sham-damaged group. The ulcer index （UI） of gastric mucosa, the activity of superoxide dismutase （SOD） and the content of malonic dialdehyde （MDA） were measured in all the groups. RESULTS： In comparison with that in stress group, the UI in EA group was significantly reduced （t = 9.5071, P 〈 0.01）, as well as the MDA content （t = 2.3578, P 〈 0.05）, but the activity of SOD was increased （t = 3.8729, P 〈 0.01）. As compared with those in NTS sham-damaged and EA group, the UI and MDA content were markedly increased （UI： t = 4.4223, 7.2579, both P 〈 0.01; MDA： t = 2.9045, 2.4960, both P 〈 0.05） in NTS electricity-damaged group, while the activity of SOD was decreased （t = 3.5625, 3.7242, P 〈 0.01）. CONCLUSION： Electrolytic lesion of NTS results in weakened effects of electroacupucturing Zusanli point in the treatment of gastric stress ulcer.

关 键 词：孤束核 电损毁 电针 应激性胃溃疡 

分 类 号：R245[医药卫生—针灸推拿学]