含羟基和咪唑基团新手性肽核酸的设计与合成  

Design and Synthesis of New Chiral Peptide Nucleic Acids Containing Hydroxyl and Imidazole Groups

作　　者：孟庆国[1] 许笑宇[2] 梁远军[2] 刘克良[2] 

机构地区：[1]烟台大学药学院,烟台264005 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《有机化学》2006年第6期845-847,共3页Chinese Journal of Organic Chemistry

摘　　要：以含丝氨酸和组氨酸残基的手性肽核酸单体替换经典肽核酸单体,采用固相合成方法设计合成了五个新序列含羟基和咪唑基团的10聚体手性肽核酸,经ESI-MS或MALDI-TOF-MS证实目标物结构正确.Five new 10-mer chiral peptide nucleic acid （PNA） sequences containing hydroxyl and imidazole groups were designed and synthesized by solid phase synthesis method after the classical PNA monomers were replaced by chiral PNA monomers containing serine or histidine residue. The structures of PNA analogues were confirmed by ESI-MS or MALDI-TOF-MS.

关 键 词：手性肽核酸 羟基 咪唑 合成 

分 类 号：O629.7[理学—有机化学]