排石(金车)颗粒解热、利尿、排石、抗炎和镇痛作用的实验评价  

Evaluations of granules for removing calculus:antipyresis,diuresis,removing urinary calculus,anti-inflammation and analgesia in rats

作　　者：吴钊华[1] 关骏良[1] 张军[2] 

机构地区：[1]广东省开平市中心医院药剂科,开平529300 [2]广州中医药大学,广州510405

出　　处：《中国新药杂志》2006年第10期780-783,共4页Chinese Journal of New Drugs

基　　金：广东省中医药局基金(103128)

摘　　要：目的:研究排石(金车)颗粒的解热、利尿、排石、抗炎和镇痛作用。方法:采用角叉菜胶致热法、利尿试验、二甲苯致小鼠耳肿胀法、角叉菜胶致大鼠足跖肿胀法、扭体法、热板法等多种动物模型和方法;并给予大鼠乙二醇和氯化铵,连续30 d,以形成结石模型进行排石试验。结果:排石颗粒在3和6 g·kg^(-1)剂量灌胃给药对实验大鼠和小鼠有显著的解热、利尿、排石、抗炎、镇痛作用。结论:排石颗粒对泌尿系统结石具有一定的治疗作用。Objective：To assess the effects of granules for removing calculus （Paishi granules） as an antipyretic, anti-inflammatory, diuretic, anti-calculous and analgesic agent. Methods： Several methodologies to evaluate the effects of Paishi granules were conducted, including pyretogenesis induced by carrageenin, mouse ear edema induced by xylene, paw edema induced by carrageenin, diuretic test, writhing method and hot-plate test. The effectiveness of removing calculus was assessed following after the administration of glycol and ammonium chloride to rats for 30 days. Results： Paishi granules 3 and 6 g·kg^-1 showed antipyresis, diuresis, removing urinary calculus, anti-inflammation and analgesia. Conclusion：Paishi granules are effective for the removal of urinary calculus.

关 键 词：排石(金车)颗粒 利尿 排石 

分 类 号：R285.5[医药卫生—中药学] R289.5[医药卫生—中医学]