胸腺T细胞分化发育的神经内分泌调控  

Neuroendocrine Control of Differentiation and Development of Thymus T Lymphocyte

作　　者：周瑞祥[1] 林建银[2] 

机构地区：[1]福建医科大学解剖与组织胚胎学系,福建福州350004 [2]福建医科大学分子医学研究中心,福建福州350004

出　　处：《解剖科学进展》2006年第2期168-171,174,共5页Progress of Anatomical Sciences

基　　金：福建省自然科学基金(C0410028);福建省教育厅基金(k02067)

摘　　要：胸腺对机体免疫功能起着不可替代的作用,胸腺细胞的分化发育成熟过程接受神经内分泌调控,神经内分泌影响胸腺细胞增殖。激素和神经肽受体在胸腺细胞上表达,参与调控胸腺内分泌功能,本文对神经内分泌对胸腺细胞分化发育的影响及其可能的机制进行了讨论。Thymus is the unique lymphoid organ responsible for the generation of a diverse repertoire of T lymphocytes that are important for the establishment and exertion of organism＇s immune function. Many data demonstrate that differentiation and development of T cells in thymus were controlled by neuroendocrine. In this review, we summarize that the influence and mechanism of neuroendocrine system on the differentiation and development of thymus T lymphocyte, including expression of hormone and neuropeptide receptors in thymus, control of hormone and neuropeptide on the thymic endocrine function, influence of neuroendocrine the proliferation of thymic cells and modulatien on the intrathymic T cell differentiation.

关 键 词：神经内分泌调控 胸腺T细胞 分化发育 胸腺细胞增殖 胸腺内分泌功能 机体免疫功能 神经肽受体 成熟过程 可替代 

分 类 号：R339.38[医药卫生—人体生理学] R730.21[医药卫生—基础医学]