去痛片（索密痛）的胶束动电毛细管色谱测定  

Determination of an Antipyretic-analgesic Compound Preparation-Qutong Pian (Saridon) with Micellar Electrokinetic Capillary Chromatography

作　　者：邹定[1] 吴学军[1] 南国柱[1] 

机构地区：[1]北京医院药检科

出　　处：《药物分析杂志》1996年第2期92-94,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：本文应用胶束动电毛细管色谱法分析去痛片（索密痛）。选择十二烷基硫酸钠为胶束相，运行液为０．０２ｍｏｌ／Ｌ磷酸盐缓冲液（ｐＨ＝１０．０），恒定电压１６ｋＶ（电流１０５～１１５μＡ），可使样品中４个组分完全分离，保留时间分别在６～１１ｍｉｎ内，ＲＳＤ均小于０．５％（ｎ＝１０）．各组分溶液在２５～５００μｇ／ｍｌ范围内浓度与峰面积之间有良好的线性关系。选用乙酰苯胺为内标物，测定样品含量。批内各组分测定值的ＲＳＤ均小于１％（ｎ＝９）。The determination of an antipyretic-analgesic compound preparation-Qutong Pian (saridon) with micellar electrokinetic capillary chromatography was described. The complete separation of four components was achieved with 0. 05 mol/L sodium dodecyl sulfate (SDS) solution as micellar phase, 0. 02 mol/L pH10. 0 running phosphate buffer and a constant voltage of 16kV (current of 105～115μA) . The retention times of individual components were between 6 and 11 minutes with relative standard deviations (RSD) less than 0. 5% (n= 10) respectively. The good linearity was shown between the concentration and peak area in the concentration range over 25～500μg/ml. Using acetanilide as internal standard, RSD of each of the four components was less than 1%. The analytical results obtained were in agreement with those by standard method.

关 键 词：胶束动电 毛细管色谱 去痛片 索密痛 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]