蛋白质营养不良大鼠血浆蛋白水平与细胞免疫功能的动态变化  

THE DYNAMIC CHANGES OF PLASMA PROTEIN LEVELS AND CELLULAR IMMUNITY IN PROTEIN DEFICIENT RATS

作　　者：郭长江[1] 徐琪寿[1] 韦京豫[1] 葛玉章[1] 杨继军[1] 顾景范[1] 

机构地区：[1]天津卫生学环境医学研究所

出　　处：《营养学报》1996年第1期30-34,共5页Acta Nutrimenta Sinica

基　　金：军队"八五"规划协作项目

摘　　要：大鼠喂以５％酪蛋白饲料造成蛋白质营养不良，与喂以２０％酪蛋白饲料大鼠比较，观察了血浆蛋白水平，外周血Ｔ淋巴细胞亚群及转化反应的动态变化。实验结果表明，血浆前白蛋白、Ｔ淋已细胞ＣＤ＿４亚群及Ｔ淋巴细胞转化反应对蛋白质营养不良较为敏感，５％蛋白水平饲料喂养三天后就显著下降，Ｔ淋巴细胞转化反应早期下降后尚有反弹现象；改喂２０％蛋白水平饲料一周后，血浆蛋白均恢复至正常水平，Ｔ淋巴细胞ＣＤ＿４亚群及转化反应恢复缓慢。hanges of plasma prealbumin,transferrin and albumin levels, periphe-ral T lymphocyte CD4,CD8 subsets and biastogenesis stimulated by Con A investigated in rats were fed on 5%and 20% casein diets.Plasma preal-bumin,T lymphocyte CD4 subset and blastogenesis were very sensitive to protein malnutrition,They were decreased significant after the rats fed on 5%casein diet for 3 days. However,the T lympbocyte blastogenesis exhibited a remarkabl e rebound shortly after its decline and decreased again thereaf-ter. All plasma proteins returned to normal after the diet had been changed to 20%casein for one week,but the T lymphocyte CD4 subset and blasto一genesis did not restored completely.

关 键 词：蛋白质缺乏病 大鼠 血浆蛋白 细胞免疫 

分 类 号：R591.2[医药卫生—内科学]