大鼠闪光视诱发电位检测方法的建立和应用  

Measurements of Flash Visual Evoked Potentials in Rats Chronically Intoxicated by Lead

作　　者：肖杭[1] 杨永年[1] 陆巍[1] 程健[1] 袁孝如[2] 

机构地区：[1]南京医科大学公共卫生学院毒理学教研室,南京210029 [2]南京医科大学生理学教研室,南京210029

出　　处：《南京医科大学学报（自然科学版）》1996年第3期250-252,共3页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：将"模式翻转视诱发电位人体临床检测系统"用于大鼠视路神经毒理的研究,建立了在本实验室检测参数下,正常大鼠闪光视诱发电位(FVEP)值,并观察了42例铅染毒3个月大鼠的FVEP,试验显示大鼠 FVEP 波形特征和人相似,但潜伏期和波幅值有差异。血铅(281.1±10.4)μg/L、脑铅(86.3±11.5)μg/L 时,FVEP 发生显著改变。视觉电位人体检测方法经改进后可适用于大鼠神经毒理研究。Statistical data of Flash Visual Evoked Potentials(FVEP)of 28 normal and 42 lead exposed rats were reported,Lead levels in blood and brain of rats were determined.The animals were given lead acetate water at three differential doses as their sole source of fluid for 3 months.The results showed that the latency of P_(100)and N_(125)wave were prolonged,with de- creased amplitudes in exposed rats with blood levels at 281.1±10.4 and 501.1±35.5 μg/L. These data implied that the FVEP may be useful in the early diagnosis of subclinical lead poison- ing.

关 键 词：铅中毒 视路诱发电位 神经毒理 大鼠 

分 类 号：R135.11[医药卫生—劳动卫生] R135.92[医药卫生—公共卫生与预防医学]