β-邻苯二甲酰亚胺基丙醛缩乙二醇的新合成方法  

A novel synthesis of 2-(2-phthalimidoethyl)-1,3-dioxolane

作　　者：曾向潮[1] 刘珀润[1] 

机构地区：[1]暨南大学化学系,广东广州510632

出　　处：《化学试剂》2006年第5期313-314,共2页Chemical Reagents

摘　　要：以四丁基溴化铵为相转移催化剂,无水K2CO3为碱性催化剂,邻苯二甲酰亚胺与β溴代丙醛缩乙二醇经Gabriel反应合成了标题化合物。在邻苯二甲酰亚胺与β溴代乙二醇缩丙醛的物质的量比为1.1∶1,反应温度100～103℃,反应时间3.5h,在此条件下,收率达95.9%。2-（2-phthalimidoethyl）-1, 3-dioxolane was synthesized by Gabriel reaction with a mixture of phthalimide, 2-（2-phthalimidoethyl）-1, 3-dioxolane and K2CO3 using TBAB as the phase transfer catalyst. The results showed that when the molar ratio of phthalimide to 2-（2-phthalimidoethyl）-1, 3-dioxolane was 1.1 ： 1, reaction temperature 100～103℃, reaction time 3.5h, the yield of the title compound was 95.9 %.

关 键 词：β-邻苯二甲酰亚胺基丙醛缩乙二醇 Gabriel反应 相转移催化 合成 

分 类 号：O625.63[理学—有机化学]