补肾活血方对实验性骨性关节炎组织测量学指标的影响  

Effect of Bushen Huoxue Fang on Histomorphometric Indexes in Experimental Osteoarthritis

作　　者：邵敏[1] 陈随星 牛维[1] 黎高明[1] 

机构地区：[1]广州中医药大学附属骨伤科医院,广东广州510240 [2]广东省汕尾市海丰县中医院

出　　处：《安徽中医学院学报》2006年第3期31-33,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：广东省自然科学基金项目(020791);国家中医药管理局科学技术研究专项基金项目(0203JP33)

摘　　要：目的:探讨补肾活血中药对实验性骨性关节炎组织形态测量学指标的影响。方法:将20只新西兰白兔随机分为中药组和对照组,两组中每只白兔随机选取一侧膝关节切断其前交叉韧带,另一侧膝关节作假手术。手术4周后,中药组白兔口饲补肾活血中药煎液,对照组予以口服9.0g/L氯化钠注射液,1次/d,共4周。作双侧膝关节大体形态学观察,测量股骨内髁软骨厚度和面积、关节滑膜细胞层厚度。结果:两组伤侧股骨内髁表面可见纤维沉积、骨赘和骨刺,滑膜增厚和充血,以对照组为明显;对照组伤侧软骨厚度和面积明显减少;两组伤侧股骨内髁滑膜细胞层明显增厚。结论:补肾活血中药有助于减轻骨性关节炎关节软骨的缺损。Objective：To study the effect of Bushen Huoxue Fang,a traditinal Chinese Prescription for strenthening kidney and activating blood on histomorpho-metric indexes in experimental osteoarthritis. Method：Twenty rabbits were randomly divided into Chinese herbs group and control group. Their anterior cruciate ligaments were transected in unilateral knee（ injured side ）randomly and contralateral knee received sham operation（ normal side）. Four weeks after operation , the rabbits were orally administrated with solution of Chinese herbs or normal saline once daily for four weeks. Their medial femoral condyles were assessed in gross morphology and the thickness and area of articular cartilage and the thickness of synovialling cell layer were measured with histomorphometric techniques. Result： Fibrillation,osteophytes,thickening and congestion of the synovium were found on the injured side of the femoral medial condyles in two groups especially in the control group. The thickness of synovial lining cell layer significantly decreased on the injured side in the control group. The thickness of synovial lining cell layer significantly increased in both groups. Conclusion：Chinese herbs for strengthening kidney and activating blood is beneficial to decreasing defect of articular cartilage in experimental osteoarthritis.

关 键 词：骨性关节炎 补肾活血方 组织测量学 

分 类 号：R684.3[医药卫生—骨科学]