乙肝疫苗接种后无(弱)应答状况及影响因素  

Study on influence factors of status of non-response to HB vaccine

作　　者：王德全[1] 陈思东[1] 周卫平[1] 汪保国[1] 蔡旭玲[1] 许雅[1] 

机构地区：[1]广东药学院公共卫生学院,广州510224

出　　处：《中国公共卫生》2006年第6期674-675,共2页Chinese Journal of Public Health

基　　金：广东省自然科学基金(020537);广东省医学科研基金(A2002311)

摘　　要：目的探讨广东省一般人群接种乙型肝炎疫苗后无应答的状况和影响因素。方法对佛山、深圳市等地2 667人进行问卷调查和免疫学检测,并用非条件Logistic回归分析对结果进行分析。结果广东省一般人群乙型肝炎疫苗无(弱)应答率为25.38%。单因素Logistic回归分析结果表明,接种乙肝疫苗后是否产生抗-HBs与接种者的年龄、接种次数、接种部位、是否输过血制品、餐具是否经常消毒、父亲是否接种过疫苗、父母接种乙肝疫苗后有无抗体等9个因素有关。多因素Logistic回归分析结果显示,年龄大、不喜欢吃鱼和父亲未接种乙肝疫苗是无应答的影响因素。结论接种乙肝疫苗后是否产生抗体与疫苗因素、饮食因素、机体发育和遗传因素都有密切关系。Objective To study the status of non-response to HBV vaccine and the factors of non-responders with HBV vaccine in Guangdong province. Methods 2 667 persons were investigated in Guangdong province, non-condition logistic regression analysis was used to analysis the reason of non-responders with HBV vaccine. Results The results of non-responder rate was 25.38 % in Guangdong province. Univariate logistic regression analysis indicated that the impact factors of anti-HBs production correlated with age, vaccination, frequency of inoculation, location of inoculation, input medicine made by blood,frequency of disinfection of dishware, father with vaccination and anti-HBs production of parent with vaccination. The result of multivariate logistic regression analysis indicated that dangerous factors were age, father with non-vaccination and heredity factors. Conclusion The impact factors of anti-HBs production correlated with vaccine, foods, individual and heredity factors.

关 键 词：乙型肝炎疫苗 无应答 影响因素 

分 类 号：R186[医药卫生—流行病学]